Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel L-SPD (cas 16562-13-3) derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles
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Add time:08/11/2019 Source:sciencedirect.com
A novel scaffold derived from L-SPD (cas 16562-13-3) with a substituted thiophene group in the D ring were designed, synthesized, and evaluated for their binding affinities at dopamine (D1, D2 and D3) and serotonin (5-HT1A and 5-HT2A) receptors. Most of the tetracyclic compounds exhibited higher affinities for D2 and 5-HT1A receptors than l-SPD, while compound 23e showed the highest Ki value of 7.54 nM at D2 receptor which was 14 times more potent than l-SPD. Additionally, compounds 23d and 23e were more potent than l-SPD at D3 receptor. According to the functional assays, 23d and 23e were demonstrated as full antagonists at D1 and D2 receptors and full agonists at 5-HT1A receptor. Since the combination of D2 antagonism and 5-HT1A agonism is considered effective in treating both the positive and negative symptoms of schizophrenia, these novel compounds are implicated as potential therapeutic agents.
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