The disposition and metabolism of 1,3-Dibromobenzene (cas 108-36-1) in the rat
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Add time:08/19/2019 Source:sciencedirect.com
The distribution, excretion and metabolism of 1,3-Dibromobenzene (cas 108-36-1) following a single i.p. administration to rats 100 or 300 mg/kg was investigated using radiotracer [3H] and GC-MS technique.After 72 hours about 74 to 90% were excreted in urine. The highest radioactivity was observed in the liver, kidneys and fat tissue. Later on a steady decline of radioactivity was apparent in all investigated tissues except for blood cells and the sciatic nerve, where constant levels were noted.In urine the following substances were identified and quantified by GC peak areas: unchanged 1,3-DBB (18%), dibromophenols (34%), dibromothiophenols (28%), dibromothioanisole (1,8%), bromophenol (5,5%), bromohydroxythiophenols (5%), and bromohydroxythioanisole (7,5%).
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