Simultaneous chemiluminescence determination of THEBAINE (cas 115-37-7) and noscapine using support vector machine regression

Add time:08/31/2019    Source:sciencedirect.com

In this work, a batch chemiluminescence (CL) method has been proposed for the simultaneous determination of two structurally similar alkaloids, noscapine and THEBAINE (cas 115-37-7). The method is based on the kinetic distinction of the CL reactions of noscapine and thebaine with Ru(bipy)32+ and Ce(IV) system in a sulfuric acid medium. The least squared support vector machine (LS-SVM) regression was applied for relating the concentrations of both compounds to their CL profiles. The parameters of the model consisting of σ2 and γ were optimized by constructing LS-SVM models with all possible combinations of these two parameters to select the model with the minimum root mean squared error of cross validation (RMSECV) as the best. The parameters of this model were then selected as optimized values. Under the optimized experimental conditions for both compounds, the detection limits obtained using the LS-SVM regression were 0.08 and 0.1 μmol L−1 for noscapine and thebaine, respectively. The proposed method was utilized for the simultaneous determination of the compounds in pharmaceutical formulations and plasma samples with satisfactory results.

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