Report on therapyUse of Edrophonium chloride (cas 116-38-1) (Tensilon) to detect early digitalis toxicity☆

Add time:08/26/2019    Source:sciencedirect.com

Edrophonium chloride (cas 116-38-1) (Tensilon), a short-acting acetylcholinesterase inhibitor, was given to 30 patients at various stages of digitalization. The results are similar to those reported with carotid sinus stimulation. Although slowing of the ventricular rate after edrophonium was most marked in patients close to full digitalization, this response is too variable to be used as a guide to digitalization. Edrophonium increased the incidence of variable and fixed coupled premature ventricular beats in patients with digitalis intoxication but not in other patients. A plan is presented for the diagnosis of digitalis intoxication that involves the use of vagal stimulation by carotid sinus stimulation and administration of edrophonium.

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