Chapter 14 - Wildlife Toxicity Assessment for 2-Nitrodiphenylamine (cas 119-75-5) and 4-Nitrodiphenylamine

Add time:08/28/2019    Source:sciencedirect.com

This chapter presents the Wildlife Toxicity Assessment (WTA) for 2- and 4-nitrodiphenylamine (NDPA). Whereas 2-NDPA is used as a stabilizer for Otto Fuel II, 4-NDPA is strictly an industrial chemical intermediate. This WTA addresses only mammals, as data for amphibians, reptiles, and birds were lacking. Data for 2-NDPA were limited to acute oral lethal dose (LD)50 values in rats. Data for 4-NDPA consisted of acute, subchronic, and developmental studies on a single species (e.g., rats). Limited inhalation and dermal data for rats were also available for 4-NDPA. Both 2- and 4-NDPA are relatively nontoxic. Feeding studies suggest 4-NDPA reduces palatability; therefore, exposures that may cause adverse effects are unlikely. No observed adverse effect levels and lowest observed adverse effect levels (NOAEL and LOAEL) of 250 and 1,000 milligrams per kilogram per day (mg/kg/day) were identified for maternal survival and growth, and fetal growth and development in rats exposed to 4-NDPA during days 6 through 15 of gestation. Toxicity Reference Values (TRVs) were developed based on these values following application of an uncertainty factor of 10 to account for interspecies variability.

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