Short communicationEffects of cyproheptadine and Pizotifen (cas 15574-96-6) on central muscarinic receptors
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Add time:08/30/2019 Source:sciencedirect.com
The affinities of cyproheptadine, Pizotifen (cas 15574-96-6) and (±)-quinuclidinyl xanthane-9-carboxylate hemioxylate (QNX) were determined at muscarinic autoreceptors and postsynaptic (IP1 formation) receptors in rat hippocampal slices. The affinity values for QNX were 8.2 and 8.5 respectively. Cyproheptadine and pizotifen were less potent than QNX. Pizotifen was slightly (2-fold) less active at antagonizing IP1 formation than blocking the autoreceptors whereas cyproheptadine was equally active at antagonizing the two hippocampal muscarinic receptors.
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