NotesLiquid Chromatographic Determination of noxytiolin (cas 15599-39-0) and 1-Methyl-2-Thiourea in Serum: Application to Pharmacokinetic Studies in Rabbits and Humans
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Add time:09/01/2019 Source:sciencedirect.com
A high-performance liquid chromatographic method is described which determines noxytiolin (cas 15599-39-0) and 1-methyl-2-thiourea concentrations in serum. Valid determination requires immediate ultracentrifugation of blood samples, rapid serum freezing, and injection into the chromatograph within 6 h. A number of pharmacokinetic parameters were calculated from serum concentration data in rabbits and humans. An unknown metabolite was detected in both species but its structure was not identified.
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