plantamajoside (cas 104777-68-6) inhibits lipopolysaccharide-induced epithelial-mesenchymal transition through suppressing the NF-κB/IL-6 signaling in esophageal squamous cell carcinoma cells
-
Add time:09/06/2019 Source:sciencedirect.com
plantamajoside (cas 104777-68-6) (PMS) is a major compound of Plantago asiatica and possesses anti-tumor activity. However, the effect of PMS on esophageal squamous cell carcinoma (ESCC) and the underlying mechanism of action are unclear. The present study aimed to evaluate the effect of PMS on lipopolysaccharide (LPS)-induced epithelial-mesenchymal transition (EMT) in ESCC. The results showed that PMS inhibited viability of ESCC cell lines (Eca-109 and TE-1) in a concentration-dependent manner. PMS also inhibited LPS-induced EMT in ESCC cells. PMS inhibited LPS-induced activation of the NF-κB pathway and IL-6 expression. PMS also suppressed IL-6-induced EMT in ESCC cells. Treatment of BAY11-7082 (an inhibitor of NF-κB) or antibody against IL-6 alleviated the effect of LPS-induced EMT in ESCC cells. Besides, inhibition of NF-κB decreased IL-6 expression. In conclusion, the results indicated that PMS inhibited LPS-induced EMT through suppressing the NF-κB/IL-6 signaling in ESCC cell lines, suggesting that PMS might be a useful agent for the treatment of ESCC.
We also recommend Trading Suppliers and Manufacturers of plantamajoside (cas 104777-68-6). Pls Click Website Link as below: cas 104777-68-6 suppliers
Prev:Nephroprotection of plantamajoside (cas 104777-68-6) in rats treated with cadmium
Next:Structure and antibacterial activity of plantamajoside (cas 104777-68-6), a caffeic acid sugar ester from Plantago major subs major) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Structure and antibacterial activity of plantamajoside (cas 104777-68-6), a caffeic acid sugar ester from Plantago major subs major09/07/2019
- Nephroprotection of plantamajoside (cas 104777-68-6) in rats treated with cadmium09/05/2019
- Pharmacokinetics of plantamajoside (cas 104777-68-6) and acteoside from Plantago asiatica in rats by liquid chromatography–mass spectrometry09/04/2019
- plantamajoside (cas 104777-68-6) ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation09/03/2019
- Invited mini reviewplantamajoside (cas 104777-68-6) — A current review09/02/2019
- plantamajoside (cas 104777-68-6) attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway09/01/2019
- plantamajoside (cas 104777-68-6) attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway08/31/2019