In vivo effects of NEOMYCIN SULFATE (cas 1404-04-2) on non-specific immunity, oxidative damage and replication of cyprinid herpesvirus 2 in crucian carp (Carassius auratus gibelio)
-
Add time:09/02/2019 Source:sciencedirect.com
Neomycin belongs to the family of 2-deoxystreptamine-containing aminoglycoside antibiotics. It is widely used for bacterial infections, targeting most gram-negative and some gram-positive bacteria. Neomycin has also been reported to show antiviral activity. Here, we evaluated the toxicity of NEOMYCIN SULFATE (cas 1404-04-2), and investigated its effect on non-specific immunity and viral infection in crucian carp (Carassius auratus gibelio). The safe concentration of neomycin sulfate for crucian carp was determined to be 102.9 mg/kg in vivo. In oxidative damage assays, neomycin sulfate increased superoxide dismutase and catalase activity and decreased malondialdehyde in the liver of crucian carp. In non-specific blood immune assays, the white blood cell count and complement 3 content significantly increased after neomycin sulfate treatment, while no significant changes were observed in antibacterial or lysozyme activity. In a challenge test, neomycin sulfate protected the crucian carp from cyprinid herpesvirus 2 (CyHV-2) infection and inhibited CyHV-2 replication. In cytotoxicity assays, low concentrations of neomycin sulfate had no cytotoxicity on cells from the fins of crucian carp. The results of the present study indicate that oral administration of neomycin sulfate reduced oxidative damage, enhanced immunity and provided protection against CyHV-2 in crucian carp.
We also recommend Trading Suppliers and Manufacturers of NEOMYCIN SULFATE (cas 1404-04-2). Pls Click Website Link as below: cas 1404-04-2 suppliers
Prev:Monitoring of NEOMYCIN SULFATE (cas 1404-04-2) antibiotic in microbial fuel cells
Next:ResearchShort CommunicationShort communication: Roles of outer membrane protein W (OmpW) on survival and biofilm formation of Cronobacter sakazakii under NEOMYCIN SULFATE (cas 1404-04-2) stress) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Development of a liquid chromatographic method for ear drops containing neomycin sulphate, polymyxin B sulphate and dexamethasone sodium phosphate09/08/2019
- Suitability of a liquid chromatography assay of NEOMYCIN SULFATE (cas 1404-04-2) to replace the microbiological assay for neomycin in USP Monographs☆09/07/2019
- Simultaneous determination of NEOMYCIN SULFATE (cas 1404-04-2) and polymyxin B sulfate by capillary electrophoresis with indirect UV detection09/06/2019
- Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of NEOMYCIN SULFATE (cas 1404-04-2)09/05/2019
- A simple and selective resonance Rayleigh scattering-energy transfer spectral method for determination of trace NEOMYCIN SULFATE (cas 1404-04-2) using Cu2O particle as probe09/04/2019
- ResearchShort CommunicationShort communication: Roles of outer membrane protein W (OmpW) on survival and biofilm formation of Cronobacter sakazakii under NEOMYCIN SULFATE (cas 1404-04-2) stress09/03/2019
- Monitoring of NEOMYCIN SULFATE (cas 1404-04-2) antibiotic in microbial fuel cells09/01/2019
-
Health and Chemical more >