Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, DELAVIRDINE (cas 136817-59-9) and saquinavir
-
Add time:09/08/2019 Source:sciencedirect.com
Solid lipid nanoparticles (SLNs) with complex internal phase were fabricated for formulating stavudine (D4T), DELAVIRDINE (cas 136817-59-9) (DLV), and saquinavir (SQV). The lipids including Compritol 888 ATO, tripalmitin, and cacao butter were stabilized by l-α-phospatidylcholine, cholesteryl hemisuccinate, and taurocholate to form SLNs. The results revealed that the morphology of SLNs was spheroidal with shallow surface pits. An increase in the weight percentage of Compritol 888 ATO increased the average diameter of D4T-entrapping SLNs and decreased that of DLV- and SQV-entrapping SLNs. Preservation at 4 °C over 6 weeks slightly enhanced the size of SLNs. For a specific drug, an increase in the entrapment efficiency enlarged the nanocarriers. The order of drug in the average particle diameter and in the entrapment efficiency was SQV > DLV > D4T, in general. In addition, the dissolution of the three drugs from SLNs showed the characteristics of sustained release. The order of drug in the cumulative release percentage was D4T > DLV > SQV. SLNs containing Compritol 888 ATO, tripalmitin, and cacao butter are efficient in carrying antiretroviral agents for medicinal application.
We also recommend Trading Suppliers and Manufacturers of DELAVIRDINE (cas 136817-59-9). Pls Click Website Link as below: cas 136817-59-9 suppliers
Prev:Effects of the G190A substitution of HIV reverse transcriptase on phenotypic susceptibility of patient isolates to DELAVIRDINE (cas 136817-59-9)
Next:Original articleSynthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Effects of the G190A substitution of HIV reverse transcriptase on phenotypic susceptibility of patient isolates to DELAVIRDINE (cas 136817-59-9)09/07/2019
- Original articleEfficacy and safety of combination therapy with DELAVIRDINE (cas 136817-59-9) and zidovudine: a European/Australian phase II trial09/06/2019
- In vitro protein-binding characteristics of DELAVIRDINE (cas 136817-59-9) and its N-dealkylated metabolite09/05/2019