Screening and characterization of cocrystal formation of Metaxalone (cas 1665-48-1) with short-chain dicarboxylic acids induced by solvent-assisted grinding approach
-
Add time:09/24/2019 Source:sciencedirect.com
A solvent-assisted grinding approach was used to investigate the possible cocrystal formation between Metaxalone (cas 1665-48-1) and short-chain dicarboxylic acids (HOOC(CH2)nCOOH, n = 0–3). Differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) microspectroscopy, and powder X-ray diffraction (PXRD) were used to verify the cocrystal formation between metaxalone and each dicarboxylic acid. As a standard reference, a cocrystal was prepared by solvent evaporation method. The cocrystal formation was also quickly estimated by using a one-step simultaneous DSC-FTIR microspectroscopy. The present study indicates that only n = 2 of short-chain dicarboxylic acids such as succinic acid, fumaric acid and maleic acid can form a cocrystal with metaxalone through solvent-assisted grinding in a short time. Moreover, this cocrystal formation was easily screened and estimated using a unique DSC-FTIR microspectroscopy.
We also recommend Trading Suppliers and Manufacturers of Metaxalone (cas 1665-48-1). Pls Click Website Link as below: cas 1665-48-1 suppliers
Prev:A fatality involving Metaxalone (cas 1665-48-1)
Next:Short communicationMetaxalone (cas 1665-48-1) estimation in biological matrix using high-throughput LC–MS/MS bioanalytical method) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Original ArticleKinetics study of Metaxalone (cas 1665-48-1) degradation under hydrolytic, oxidative and thermal stress conditions using stability-indicating HPLC method10/01/2019
- Solubilities of chlormezanone, Metaxalone (cas 1665-48-1) and methocarbamol in supercritical carbon dioxide09/27/2019
- Synthesis of poly(ethylene glycol)–Metaxalone (cas 1665-48-1) conjugates and study of its controlled release in vitro09/26/2019
- Short communicationMetaxalone (cas 1665-48-1) estimation in biological matrix using high-throughput LC–MS/MS bioanalytical method09/25/2019
- A fatality involving Metaxalone (cas 1665-48-1)09/10/2019
- Short CommunicationQuantitative determination of Metaxalone (cas 1665-48-1) in human plasma by LC-MS and its application in a pharmacokinetic study09/09/2019
- Pain management and sedation/original researchA Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone (cas 1665-48-1), Tizanidine, or Baclofen for Acute Low Back Pain09/08/2019
- Lower melting pharmaceutical cocrystals of Metaxalone (cas 1665-48-1) with carboxamide functionalities09/07/2019