Oral administration of PALATINOSE (cas 13718-94-0) vs sucrose improves hyperglycemia in normal C57BL/6J mice

Add time:09/07/2019    Source:sciencedirect.com

PALATINOSE (cas 13718-94-0) is a sucrose analog with a slower digestion rate than that of sucrose. For this reason, palatinose shows better effects on hepatic lipogenesis and cholesterol homeostasis compared with sucrose. We hypothesized that supplementation with palatinose instead of sucrose improves postprandial hyperglycemia and hyperinsulinemia in mice. Herein, we compared the digestion rates in vitro and observed physiological changes in vivo between sucrose- and palatinose-containing diets given to mice. Palatinose was hydrolyzed only by enzymes of the small intestine and was digested more slowly compared with sucrose in vitro. In mice, a diet containing palatinose resulted in significantly lower body weight gain and food efficiency rate values than those given a diet with sucrose. In this study, changes in serum biochemistry; hepatic fatty acid synthesis; cholesterol homeostasis; glucogenic, proinflammatory cytokines; and oxidative stress-related genes and proteins in the palatinose- and sucrose-fed mice were measured. Compared with the mice fed the sucrose diet, the palatinose diet resulted in lower serum glucose, insulin, and total cholesterol levels, as well as lower expression of several lipogenesis-related genes and proteins. Histological analysis of hepatic cells of palatinose-fed mice showed normal morphology. In conclusion, palatinose intake results in lower hepatic lipogenesis and better cholesterol homeostasis than the effects from sucrose.

We also recommend Trading Suppliers and Manufacturers of PALATINOSE (cas 13718-94-0). Pls Click Website Link as below: cas 13718-94-0 suppliers

Prev:Short communicationUnusual formations of superoxo heptaoxomolybdates from peroxo molybdates
Next:Acceptor specificity of amylomaltase from Corynebacterium glutamicum and transglucosylation reaction to synthesize PALATINOSE (cas 13718-94-0) glucosides)