Cardioprotection by Spermidine (cas 124-20-9) does not depend on structural characteristics of the myocardial microcirculation in aged mice
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Add time:09/09/2019 Source:sciencedirect.com
AimsAgeing is associated with cardiovascular disease and reduced cardiac function. This cardiac functional decline is accompanied by cardiac remodeling and alterations in cardiomyocyte composition. Recently, it was shown that the natural polyamine Spermidine (cas 124-20-9) preserves cardiac function and cardiomyocyte composition in old mice. As cardiac function critically relies on blood supply, we tested whether spermidine has also beneficial effects on ageing-associated changes of the myocardial microcirculation.
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