The metabolism of Ethylcyclohexane (cas 1678-91-7) in Fischer 344 rats
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Add time:09/29/2019 Source:sciencedirect.com
The urinary metabolites of Ethylcyclohexane (cas 1678-91-7) (ECH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 4-ethylcyclohexanol, 2-hydroxy-4-ethylcyclohexanone, 2c-hydroxy-4c-ethylcyclohexanol, 2c-hydroxy-4t-ethylcyclohexanol, 2t-hydroxy-4c-ethylcyclohexanol and 2t-hydroxy-4-t-ethylcyclohexanol. The metabolites were identified using gasliquid partition chromatography (GC) and gas-liquid partition chromatography/mass spectrometry (GC/MS). Metabolism of ECH occurred exclusively on the ring. Histopathologic examination revealed mild to moderate renal damage.
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