Polymorphism and Cyclodextrin Inclusion of Salbutamol Laurate
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Add time:09/28/2019 Source:infona.pl
Salbutamol laurate is a novel salt form of the well-known bronchodilator salbutamol (albuterol). Its polymorphism and inclusion in (2-hydroxypropyl)-β-cyclodextrinwere investigated by thermogravimetry, differential scanning calorimetry, infrared and powder X-ray diffraction techniques. Two polymorphic forms of the salt were identified. Conditions for inclusion complex formation between the salt and (2-hydroxypropyl)-β-cyclodextrin, namely prolonged co-grinding and kneading, were established by a combination of the above methods.
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