Sulfur rich 2-Mercaptobenzothiazole (cas 149-30-4) and 1,2,3-triazole conjugates as novel antitubercular agents
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Add time:09/29/2019 Source:infona.pl
A series of benzfused heterocyclic derivatives such as amide conjugates of 2-(benzo[d]thiazol-2-ylthio)acetic acid with aromatic/aliphatic/cyclic secondary amines (5a–5o & 8a–8m); 1,2,3-triazole conjugates of 2-Mercaptobenzothiazole (cas 149-30-4)s and amide conjugates of indole-3-glyoxalic acid with cyclic secondary amines (14a–14g) have been synthesized and were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. Compounds 8b, 8f, 8g and 8l inhibited the growth of the H37Rv strain at concentrations of 8 μg/mL. These compounds (8b, 8f, 8g and 8l) have been further identified as bactericidal and are completely killing the microbes at 32–64 μg/mL concentrations. Molecular docking studies of the active compounds reveal that these compounds are targeting DprE1 and may act as DprE1 inhibitors.
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- Investigation of Isomeric Polymers [Cd2(mbt)4] n and [Cd(mbt)2] n : The Crystal Structure of Catena-tetra (2-Mercaptobenzothiazole (cas 149-30-4)) Dicadmium, {[Cd(μ-η2-C7H4NS2)2][Cd(μ-η2-C7H4NS2) (μ3-η2-C7H4NS2)]} n 09/30/2019
- Photopolymerization of dimethacrylates in the presence of 2-Mercaptobenzothiazole (cas 149-30-4) (MBT) and 2,2'-benzothiazole disulfide (BTDS)09/28/2019