Regio‐ and Diastereoselective Organo‐Zinc‐Promoted Arylation of trans‐2,3‐Diaryloxiranes by Arylboronic Acids: Stereoselective Access to trans‐2,3‐Diphenyl‐2,3‐dihydrobenzofuran
-
Add time:09/29/2019 Source:infona.pl
ortho‐Oxo substituted trans 2,3‐diaryloxiranes were regio‐ and stereoselectively arylated by arylzinc reagents, obtained from the corresponding boronic acids by B–Zn exchange. The reaction was quite general, irrespective to the aryl nucleophile and proceeded via a ring opening at the α‐carbon with respect to the substituted aryl ring. The stereoselectivity was from high to complete toward the alcohol resulted from retention of configuration at the electrophilic carbon. The method allowed a direct and high yielding access to trans 2,3‐diphenyl‐2,3‐dihydrobenzofuran, which is a key structural motif in resveratrol dimers as viniferins. The use of enantioenriched starting diaryloxiranes resulted in no loss of stereochemical integrity in the final trans 2,3‐dihydrobenzofuran, which was characterized for the first time in enantioenriched form.
We also recommend Trading Suppliers and Manufacturers of 2,3:8,9-Di[1,3]butadienoperylene (cas 197-74-0). Pls Click Website Link as below: cas 197-74-0 suppliers
Prev:Rdz 1,1–2,3 na nowo odczytane? Czyli pytanie o to, czy możliwe jest nowe spojrzenie na kapłański opis stworzenia?
Next:A One‐pot Facile Synthesis of 2,3‐Dihydroxyquinoxaline and 2,3‐Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst) - 【Back】【Close 】【Print】【Add to favorite 】