DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands
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Add time:09/29/2019 Source:infona.pl
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = Pyrazino[2,3-f][1,10]phenanthroline (cas 217-90-3)) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated.
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- Evaluation of the potential effectiveness of ruthenium(II) complexes with 2,3-disubtituted pyrazino[2,3-f][1,10]phenanthroline anchors, R2ppl (R=CN, COOH, COOEt, OH) as sensitizers for solar cells09/30/2019
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