A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline
-
Add time:09/28/2019 Source:infona.pl
The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesised that the latter activity is due to stabilisation of an intermediate guanine-quadruplex complex, in accordance with computer modelling.
We also recommend Trading Suppliers and Manufacturers of 10H-indolo[3,2-b]quinoline (cas 243-58-3). Pls Click Website Link as below: cas 243-58-3 suppliers
Prev:Effect of the initial stage of film growth on device performance of organic transistors based on dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT)
Next:Synthesis of Some New 3,7-Bisubstituted Dibenzobromolium (cas 244-34-8) Salts.) - 【Back】【Close 】【Print】【Add to favorite 】