1.Identification
1.1 GHS Product identifier
Product name | chlordecone |
---|
1.2 Other means of identification
Product number | - |
---|---|
Other names | Merex |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. Pesticides (chemicals used for killing pests, such as rodents, insects, or plants) |
---|---|
Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number | - |
---|---|
Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
Pictogram(s) | |
---|---|
Signal word | Danger |
Hazard statement(s) | H301 Toxic if swallowed H311 Toxic in contact with skin H351 Suspected of causing cancer H410 Very toxic to aquatic life with long lasting effects |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
Storage | P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
---|---|---|---|---|
chlordecone | chlordecone | 143-50-0 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Induce vomiting (ONLY IN CONSCIOUS PERSONS!). See Notes. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
INHALATION AND INGESTION: These symptoms present in all affected patients - Neurologic Impairment - anxiety, irritability, memory disturbance, headache, tremors, opsiclonus, stuttering, slurred speech, and abnormal tandem gait. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Emergency and supportive measures; 1. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. As most liquid products are formulated in organic solvents, observe for evidence of pulmonary aspiration. 2. Treat seizures, coma, and respiratory depression if they occur. Ventricular arrhythmias may respond to beta-adrenergic blockers such as propranolol or esmolol. 3. Attach an electrocardiographic monitor, and observe the patient for at least 6-8 hours /Chlorinated hydrocarbon pesticides/.
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P3 filter respirator for toxic particles.
6.3 Methods and materials for containment and cleaning up
Survey reports six case histories employing EPA's hazardous materials spills treatment trailer are reviewed. The trailer's ... treatment system has three mixed-media filters and three activated carbon columns to remove suspended, precipitated, and organic soluble materials. Spills of PCB, pentachlorophenol, kepone, termide (chlordane), heptachlor, aldrin, and dieldrin, toxaphene, and dinitrobutylphenol were treated by the EPA trailer, which was generally successful in mitigating environmental effects by filtering and carbon-adsorption. 90% removal was achieved for 21 of 23 compounds.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from acids.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
NIOSH considers kepone to be a potential occupational carcinogen.
Recommended Exposure Limit: 10 Hr Time-Weighted avg: 0.001 mg/cu m.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | Kepone is an odorless colorless crystalline solid. (USCG, 1999) |
---|---|
Colour | Crystals |
Odour | Odorless |
Melting point/ freezing point | 350oC (decomp) |
Boiling point or initial boiling point and boiling range | 459.7oC at 760 mmHg |
Flammability | Noncombustible SolidGives off irritating or toxic fumes (or gases) in a fire. |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | >100oC |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | no data available |
Solubility | less than 1 mg/mL at 22.78°C |
Partition coefficient n-octanol/water (log value) | log Kow = 5.41 |
Vapour pressure | 1.24E-08mmHg at 25°C |
Density and/or relative density | 2.27g/cm3 |
Relative vapour density | 16.94 (Relative to Air) |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable to about 350°C; readily hydrates on exposure to room temp & humidity
10.3 Possibility of hazardous reactions
NON-FLAMMABLEA halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Acids, acid fumes.
10.6 Hazardous decomposition products
Decomposes at 350°C.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 95 mg/kg
- Inhalation: no data available
- Dermal: LD50 Rabbit (male) percutaneous 410 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
NTP: Reasonably anticipated to be a human carcinogen
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Salmo gairdnerii (Rainbow trout, 1.1 g) 30 ug/L/96 hr @ 12°C (95% confidence limit 24-38), static /Technical material, 90.7%
- Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (first instar) 260 ug/L/48 hr @ 17°C (95% confidence limit 200-345 ug/L), static /Technical material, 90.7%
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Kepone is not expected to be susceptible to biodegradation under aerobic conditions. An experiment using activated sludge found that <0.1% of the applied kepone was metabolised after three days(1). A similar study employed a freshwater laboratory microcosm and the results showed a half-life in estuarine sediments for kepone to be >312 days(2). In a study conducted on James River sediments with added autoclaved silty loam soil, kepone showed no degradation after 52 days at pH=7(3). Hydrosoils from a reservoir with no prior exposure to kepone and that were subsequently exposed to kepone and hydrosoils from a kepone-contaminated creek both showed no biodegradation under aerobic conditions after 56 days(4). The amount of kepone recovered from sea water under aerobic conditions for 1 year was 95%(5).
12.3 Bioaccumulative potential
A BCF range from 900-13,500 was measured for kepone(1) using sheepshead minnows, spot fish, and oysters(1). Other reported BCFs of kepone: fathead minnow, 1,100-2,200(2); Cyprinodon variegatus, 1,548, Leiostomus xanthrus, 1,221; Palaemonetes pugio, 698, Callinectes sapidus, 8.1(4); no species reported, 8,400(3); Brevoortia tyrannus (Atlantic menhaden), 2,300-9,750; Menidia menidia (Atlantic silversides), 217,00-602,00(5). According to a classification scheme(6), these BCFs suggest that bioconcentration in aquatic organisms is high to very high(SRC).
12.4 Mobility in soil
The Koc of kepone is estimated as 21,000(SRC), using a log Kow of 5.41(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that kepone is expected to be immobile. Percent kepone leached through soil cylinders 80 cm deep: clay loam, 1.2%; clay, 17.2%; sandy clay loam, 36.8%; sandy loam, 28.1%(4).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN2761 | IMDG: UN2761 | IATA: UN2761 |
14.2 UN Proper Shipping Name
ADR/RID: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC |
IMDG: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC |
IATA: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC |
14.3 Transport hazard class(es)
ADR/RID: 6.1(b) | IMDG: 6.1(b) | IATA: 6.1(b) |
14.4 Packing group, if applicable
ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
---|---|---|---|
chlordecone | chlordecone | 143-50-0 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
China Catalog of Hazardous chemicals 2015 | Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. |
16.Other information
Information on revision
Creation Date | Aug 18, 2017 |
---|---|
Revision Date | Aug 18, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/