1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

Acute toxicity - Dermal, Category 1

Skin irritation, Category 2

Serious eye damage, Category 1

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 2

Germ cell mutagenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H310 Fatal in contact with skin H315 Causes skin irritation H318 Causes serious eye damage H317 May cause an allergic skin reaction H330 Fatal if inhaled H341 Suspected of causing genetic defects H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P310 Immediately call a POISON CENTER/doctor/… P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Dinitrophenol and Related Compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Keep run-off water out of sewers and water sources.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Environmental considerations: Land spill: Dig a pit, pond lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs. Well closed.You should protect this material from exposure to light, and store it in a refrigerator.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.2 mg/cu m, skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable during transport.

10.3 Possibility of hazardous reactions

Dust explosion possible if in powder or granular form, mixed with air.This compound is incompatible with the following: Strong oxidizers (NIOSH, 2016). Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. 4,6-DINITRO-O-CRESOL is explosive and is usually moistened with up to 10 percent water to reduce the hazard. [EPA, 1998].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizers.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat oral 10 mg/kg.
• Inhalation: no data available
• Dermal: LD50 Rabbit percutaneous 1,000 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Danio rerio (Zebra danio) length 2.5 cm; Conditions: freshwater, static, 22°C, pH 7.8-8, hardness 150 mg/L CaCO3; Concentration: 1000-3500 ug/L for 24 hr
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 2300 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: In a static-culture flask-screening procedure using a settled wastewater innoculum and a 7-day static incubation followed by three weekly subcultures, an initial 4,6-dinitro-o-cresol concentration of 5 ppm was degraded 52, 58, 56, and 51% in the original, first, second, and third subcultures after 7 days, respectively(1). With an initial concentration of 10 ppm, degradation was 0, 5, 11, and 14% after 7 days for the original, first, second, and third subcultures, respectively(1). 4,6-Dinitro-o-cresol was considered difficult to degrade, <20% elimination, within the prescribed test period, with the Zahn-Wellens test(2). A theoretical BOD of 22.3% was measured in a Warburg respirometer over a 3 hr incubation period using an initial concentration of 100 ppm and a mixed bacteria culture adapted to phenol(3). Mixed bacteria cultures (primarily Pseudomonadaceae) obtained from mud, soil, and water degraded only 1% of initial 4,6-dinitro-o-cresol (207 ppm) in 48 hr static flask tests using mineral solutions and 4,6-dinitro-o-cresol as the only carbon source(4). An activated sludge system receiving an influent of 11 ppb 4,6-dinitro-o-cresol was able to degrade 99% of the compound(5). In neutral and mildly alkaline soils, doses of 10-150 ppm 4,6-dinitro-o-cresol increased CO2 output by 10-30% over control, although there was a lag period before stimulation at concentrations above 50 ppm; in acidic soil, only low concentrations (1-20 ppm) produced significant stimulation(6). 4,6-Dinitro-o-cresol was found to increase CO2 production from soil microflora at low concentrations, but decrease at high concentrations(7). Biodegradation half-lives of 4,6-dinito-o-cresol in natural water were reported as 7 (aerobic) and 2.8 (anaerobic) days(8). No loss of 4,6-dinitro-o-cresol was observed when 4,6-dinitro-o-cresol was incubated in the dark with Texas soil (slightly basic sandy loam, 3.25% organic matter) and Mississippi soil (acidic soil, <1% organic matter) over a 65 day period(9). These soils had no previous exposure to industrial chemicals or wastes and did not receive any pre-treatment such as soil amendments or acclimated biological cultures(9). After a lag period of 80 days, 4,6-dinitro-o-cresol (25 ug/L) degraded quickly (rate constant 2.1 ug/L/day) under aerobic conditions in column experiments using groundwater and sediment from a shallow, unconfined, aquifer near Vejen, Denmark(10). 4,6-Dinitro-o-cresol, present at 100 mg/L, reached 4% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(11).

12.3 Bioaccumulative potential

BCF values of <0.3-0.7 at 50 ug/L and <2.9 at 5 ug/L were measured for carp after a 6 week exposure(1). Using bioaccumulation test OECD 305E, which is a dynamic flow-through test, the BCF for zebra fish (Brachydanio rerio) were calculated from the kinetics of the uptake and clearance phases and a BCF of 1.4 was found for 2,4-dinitro-o-cresol(2). BCF values ranging from 56-64 were found for Pimephales promelas (fathead minnow) after a 24-30 day exposure to 4,6-dinitro-o-cresol (0.6-7.8 ug/L)(3). A BCF of 1.5 was reported for fish(4). According to a classification scheme(5), these BCF values suggest the potential for bioconcentration in aquatic organisms is low to moderate(SRC).

12.4 Mobility in soil

Koc values for 4,6-dinitro-o-cresol derived from experimental measurements have been reported as 257(1) and 300(2). A Koc for 4,6-dinitro-o-cresol of 23 was reported for sandy loam(3). According to a classification scheme(4), these Koc values suggest that 4,6-dinitro-o-cresol is expected to have very high to moderate mobility in soil. The pKa of 4,6-dinitro-o-cresol is 4.31(5), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). In an aquifer laboratory and field study in Denmark, 4,6-dinitro-o-cresol had Kd sorption coefficient values ranging from 0.10 to 0.98 with stronger sorption occurring at lower pHs where the neutral form of the compound was at a higher percentage than at the higher pHs(7); this indicates the anionic form of 4,6-dinitro-o-cresol is more mobile in soil than the neutral form(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.