1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Dermal, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H311 Toxic in contact with skin H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Absorption, Distribution and Excretion

/In a rat metabolism study/... Preliminary study: Group A, 2 male (M)/2 female (F) exposed to a single oral dose of [14C]fluridone (...radiopurity 99.8%; for test solutions [14C]fluridone was mixed w/[12C]fluridone, ...100% purity; test substance was suspended in 1% sodium carboxymethyl cellulose [CMC]) at ~10 mg/kg. Group B, 1M/1F exposed to a single oral dose at ~1000 mg/kg. Urine, feces and cage rinses were collected daily for 7 days (because expired (trapped) 14CO2 accounted for <1% of the dose after 24 hr, further 14CO2 measurements were discontinued). Definitive study: Group C, vehicle controls, 2M/2F exposed to a single oral dose of 1% CMC. Group D, 5M/5F exposed to a single oral dose at ~7.4 mg/kg. Group E, 7M/7F exposed to ~10 mg/kg unlabeled fluridone once daily for 14 days, then 5M/5F exposed on day 15 to ~10 mg/kg [14C]fluridone. Group F, 5M/5F exposed to a single oral dose at ~900 mg/kg. ...Clinical signs (lack of mobility, abnormal and rapid head movement, squinting, loss of balance and cage biting) occurred only at the HD (Groups B and F), clearing within 24 hr. Results, Group A: by 7 days, 12.52%/12.89% (M/F) was excreted in urine and 72.76%/81.79% in feces. Group B: by 7 days 4.83%/3.43% was excreted in urine and 86.43%/86.31% in feces. Group D: by 24 hr 11.14%/10.44% was excreted in urine and 72.46%/77.72% in feces. By 7 days 11.61%/10.93% was excreted in urine and 79.19%/84.62% in feces. Combined excretion (including cage rinse) by 7 days was 92.93%/98.74%. Group E: by 24 hr 9.54%/8.51% was excreted in urine and 70.69%/69.90% in feces. By 7 days 10.11%/9.14% was excreted in urine and 79.80%/81.79% in feces. Combined excretion (including cage rinse) by 7 days was 92.81%/94.21%. Group F: by 24 hr 2.40%/2.43% was excreted in urine and 27.16%/27.18% in feces (thus, a relative delay in fecal excretion at the HD). By 7 days 8.30%/8.07% was excreted in urine and 91.58%/90.09% in feces. Combined excretion (including cage rinse) by 7 days was 101.02%/99.62%. Total tissue residues were always <1% of the dose (Groups D-F). Under all conditions, highest tissue levels occurred in the liver. The major metabolites were a variety of polar and non-polar compounds resulting from aromatic hydroxylations and heteroaromatic N-demethylation. The parent compound was the primary fecal component over the 1st 72 hr.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Keep away from children. Store in original container. Do Not contaminate water, food, feed by storage or disposal.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable to hydrolysis at pH 3-9.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic vapors of /nitrogen oxides, hydrogen fluoride/ ...

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat oral >10,000 mg/kg
• Inhalation: no data available
• Dermal: LD50 Rabbit percutaneous >5000 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50 /Oncorhynchus mykiss/ (Rainbow Trout) 11.7 mg/L/ 96 hr /Conditions of bioassay not specified in source examined
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; intoxication, immobilization) 3.6 ppm/48 hr (95% confidence interval: 3.2-4.0 ppm); static /formulated product/[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on 1-Methyl-3-phenyl-5-
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: A half-life of 12 months was reported for fluridone in sediment under laboratory conditions and 17 weeks under field conditions(1). Fluridone was reported to dissipate with average half-lives of 20 days and 3 months in pond water and in pond hydrosoil, respectively(2). A half-life of 4 days was observed for fluridone after treatment in a pond(3). A half-life of 1 year or more was observed for fluridone in hydrosoils(3). Photodegradation was found to be the major degradation pathway of fluridone in aquatic systems under actual-use conditions(1). In field studies using different soil types, <10% of the originally applied fluridone was found after 220 days in Miller clay and 20% was found remaining after 385 days in Lufkin fine sandy loam soil(4). In laboratory studies, fluridone persistence in non-sterilized soils after 210 days was 62, 44, 10, and 5% in Lufkin fine sandy loam, Miller clay, Hidalgo sandy clay loam, and Brennan fine sandy loam, respectively(4). In Miller clay and Lufkin fine sandy loam no difference was observed in the rate of fluridone degradation between sterilized and non-sterilized samples; however, noticeable differences in degradation were observed between sterilized and non-sterilized Brennan fine sandy loam and Hidalgo sandy clay loam(4). A half-life of 360 days was reported in aerobic soil(5).

12.3 Bioaccumulative potential

BCF values ranging from 0 to 91 have been reported for fluridone in various fish(1-4). According to a classification scheme(5), BCF values of <30 are low, and from 30 to 100 are moderate.

12.4 Mobility in soil

Koc values for fluridone measured in 6 soils were reported to range from 350 to 2,462(1-3). According to a classification scheme(4), these Koc values suggest that fluridone is expected to have low to slight mobility in soil. The pKa of fluridone is 12.3(5), indicating that this compound will primarily exist in the protonated form in the environment and cations generally adsorb more strongly to organic carbon and clay than their neutral counterparts(6).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.