1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Acute toxicity - Inhalation, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

Reproductive toxicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled H341 Suspected of causing genetic defects H350 May cause cancer H373 May cause damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects H361f
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P308+P313 IF exposed or concerned: Get medical advice/ attention. P314 Get medical advice/attention if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

INHALATION, INGESTION OR SKIN ABSORPTION: Headache, weakness, nausea or dizziness, cyanosis, drowsiness, shortness of breath and collapse. Can burn eyes and skin. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

In case of ingestion, induction of emesis is not recommended because of the potential for central nervous system depression. Gastric lavage and administration of activated charcoal may be considered soon after ingestion, provided airways are protected. /Dinitrotoluene/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water, carbon dioxide, or dry chemical from protected location.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Emits toxic fumes of oxides of nitrogen Behavior in Fire: May explode when exposed to heat or flame. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1) REMOVE ALL IGNITION SOURCES. 2) VENTILATE AREA OF SPILL. 3) FOR SMALL QUANTITIES, SWEEP ONTO PAPER OR OTHER SUITABLE MATERIAL & BURN IN SUITABLE COMBUSTION CHAMBER WHICH ALLOWS BURNING IN UNCONFINED CONDITION & IS EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. LARGE QUANTITIES MAY BE RECLAIMED ... IF ... NOT PRACTICAL, DISSOLVE IN FUEL OIL & ATOMIZE IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. /DINITROTOLUENE/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong bases, food and feedstuffs, oxidants and strong reducing agents. Well closed. Keep in a well-ventilated room.Storage temperture: Ambient

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers dinitrotoluene to be a potential occupational carcinogen. /Dinitrotoluene/

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Dinitrotoluene/

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 1.5 mg/cu m, skin. /Dinitrotoluene/

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

CombustibleDust explosion possible if in powder or granular form, mixed with air.2,6-DINITROTOLUENE is sensitive to heat. It may explode when exposed to heat or flame. It can be detonated only by a very strong initiator. This chemical is incompatible with strong oxidizers. It is also incompatible with caustics and metals such as tin and zinc. It may react with reducing agents. It will attack some forms of plastics, rubber and coatings.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

STABILITY: This chemical is stable under normal laboratory conditions. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This compound reacts with oxidizers, caustics, nitric acid, reducing materials and metals, such as zinc or tin. It may react violently in the presence of a base or when heated to the boiling point. It attacks some forms of plastics, rubbers and coatings.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat oral 177 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence in humans for the carcinogenicity of ... 2,6-dinitrotoluene. There is sufficient evidence in experimental animals for the carcinogenicity of ... 2,6-dinitrotoluene. Overall evaluation: ... 2,6-Dinitrotoluene /is/ possibly carcinogenic to humans (Group 2B).

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow) juvenile, length 2.4 cm, weight 0.28 g; Conditions: freshwater, static, 20.3 (19.5-22.0)°C, pH 7.6 (6.0-9.2), hardness 29.6 (12.0-43.0) mg/L CaCO3, alkalinity 31.0 (15.0-60.0) mg/L CaCO3, dissolved oxygen 7.2 (2.8-9.4) mg/L; Concentration: 18500 ug/L for 96 hr (95% confidence interval: 17200-20200 ug/L) /95-99% purity formulation
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 20000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
• Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static; 24°C, pH 8.0-9.3; Concentration: 16000 ug/L for 48 hr; Effect: population, decreased biomass /formulation
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The biodegradability of 2,6-dinitrotoluene was tested in a static screening test using flasks that contained either 5 or 10 mg/L 2,6-dinitrotoluene, 5 mg/L yeast extract and settled domestic sewage as the inoculum. Subcultures were done every 7 days. The percent biodegradation by the original culture and first, second and third subcultures at an initial 2,6-dinitrotoluene concentration of 10 mg/L was: 57, 49, 35 and 13%, respectively(1). 2,6-Dinitrotoluene at an initial concentration of 10 ug/ml (10 mg/L) did not significantly degrade after 28 days incubation with raw municipal sewage(2). In another study, 2,6-dinitrotoluene inhibited biodegradation of municipal sewage at concentrations above 50 mg/L(3). In the same study, industrial seed degraded 50 mg/L 2,6-dinitrotoluene to 25 mg/L in 2 days, but after 7 days, 2,6-dinitrotoluene concentration remained at 25 mg/L. 2,6-Dinitrotoluene was easy to degrade according to results obtained by the "cultivation method" in which 98-100% and 83-100% degradation occurred in 3 days in river water and coastal sea water in Japan, respectively(7). 2,6-Dinitrotoluene was easily degraded by microorganisms in seawater, although the 2,6-isomer was the least readily degraded than all other dinitrotoluene isomers(4). This is consistent with the observation that the rate of reduction of nitro compound increases with increasing electron withdrawing power of groups in the para position(6). Degradation in river water was generally higher than in seawater(5). No degradation rates were given. The average percent biodegradation in eleven test runs of a pilot activated sludge plant was 57%(8).

12.3 Bioaccumulative potential

An estimated BCF of 11 was calculated for 2,6-dinitrotoluene(SRC), using a log Kow of 2.10(1) and a regression-derived equation(2). The BCF for dinitrotoluene (mixed isomers) has been measured to be low (BCF values of 0.6 to 21.2) in carp (Carprinus carpio)(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low. An experimental log BCF of 2.44 (BCF of 275) (fat basis) was determined for 2,6-dinitrotoluene in the guppy (Poecilia reticulata) in a 3-day static test(5).

12.4 Mobility in soil

The Freundlich adsorption constant (exponent 1/n) for 2,6-dinitrotoluene in a Mississippi sandy loam soil (pH 5.6, organic carbon 0.94%) and a Texas sandy silt loam soil (pH 8.1, organic carbon 3.25%) was 0.014 (0.68) and 0.005 (0.61), respectively(1) which correspond to Koc values of 72 and 19, respectively(SRC). In a loamy sand soil containing an organic matter content of 8.5 g/kg, 2,6-dinitrotoluene had measured Kd adsorption coefficient 0.97 cu cm/g(2) that correspond to a Koc 197(SRC). According to a classification scheme(3), these Koc values indicate that 2,6-dinitrotoluene is expected to have very high to moderate mobility in soil. Field monitoring at a munition factory site in Melbourne Australia found that 2,6-dinitrotoluene migrated large distances in the subsurface soils(4). Leaching of 2,6-dinitrotoluene has been observed in soil column transport studies(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.