63132-85-4Relevant articles and documents
Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α-Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate
Milanole, Ga?lle,Andriessen, Floris,Lemonnier, Gérald,Sebban, Muriel,Coadou, Ga?l,Couve-Bonnaire, Samuel,Bonfanti, Jean-Fran?ois,Jubault, Philippe,Pannecoucke, Xavier
supporting information, p. 2968 - 2971 (2015/06/30)
Synthesis of fluorocyclopropyl building blocks, which constitute the core of various therapeutic agents against the hepatitis C virus, is described. The relevant methyl α-amino-β-fluoro-β-vinylcyclopropanecarboxylate has been used as a key intermediate for the total synthesis of a fluorinated analogue of Simeprevir (TMC 435), a HCV NS3/4A protease inhibitor.
Preparation of cyclopropyl sulfonylamides
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Page/Page column 2-3, (2009/05/28)
A novel process for the preparation of cyclopropyl sulfonamide of the formula I is described. Cyclopropyl sulfonamide is a versatile building block for many biologically active compounds.
Inhibitors of Hepatitis C Virus
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Page/Page column 24-25, (2008/12/04)
Macrocyclic peptides are disclosed having the general formula: wherein R3, R3′, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.