75091-93-9

Basic information

• Product Name: trans-4-(Trifluoromethyl)cyclohexanol
• Synonyms: trans-4-(Trifluoromethyl)cyclohexanol;trans (e,e)-4-trifluoromethylcyclohexanol;trans-4-(Trifluoromethyl)
• CAS NO: 75091-93-9
• Molecular Formula: C₇H₁₁F₃O
• Molecular Weight: 168.1568496
• Mol File: 75091-93-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 160.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.88±0.40(Predicted)
• CAS DataBase Reference: trans-4-(Trifluoromethyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-(Trifluoromethyl)cyclohexanol(75091-93-9)
• EPA Substance Registry System: trans-4-(Trifluoromethyl)cyclohexanol(75091-93-9)

Safety Data

• Hazardous Substances Data: 75091-93-9(Hazardous Substances Data)

Usage

General Description

Trans-4-(Trifluoromethyl)cyclohexanol is a chemical compound with the molecular formula C7H11F3O. It is a colorless liquid with a slightly sweet odor. trans-4-(Trifluoromethyl)cyclohexanol is used as a solvent, intermediate, and reagent in organic synthesis. It is also utilized in the production of pharmaceuticals and agrochemicals. Additionally, trans-4-(Trifluoromethyl)cyclohexanol is an important building block in the synthesis of various fluorinated compounds, which have applications in the pharmaceutical and agricultural industries. trans-4-(Trifluoromethyl)cyclohexanol is considered to be of low toxicity, but caution should be exercised when handling it, as prolonged exposure may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 401-75-2 trifluoromethylcyclohexane 
• 343217-50-5 Trifluoro-acetic acid 4-trifluoromethyl-cyclohexyl ester 

Downstream Products

• 75091-95-1 3,5-Dinitro-benzoic acid 4-trifluoromethyl-cyclohexyl ester 
• 75091-96-2 3,5-Dinitro-benzoic acid 4-trifluoromethyl-cyclohexyl ester 
• 30129-21-6 7,7,7-Trifluormenthan-8-ol 
• 1225357-08-3 2-bromo-6-(4-trifluoromethyl-cyclohexyloxy)-naphthalene 
• 1225350-98-0 tert-butyl 2,2-dimethyl-5-(5-(trifluoromethyl)-6-(4-(trifluoromethyl)cyclohexyloxy)naphthalen-2-yl)-1,3-dioxan-5-ylcarbamate 
• 1449736-86-0 8-nitro-4-(((1s,4s)-4-(trifluoromethyl)cyclohexyl)oxy)quinazoline 
• 1449736-87-1 8-nitro-4-(((1r,4r)-4-(trifluoromethyl)cyclohexyl)oxy)quinazoline 
• 1544009-68-8 2-bromo-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 
• 1544010-47-0 trans-4-(trifluoromethyl)cyclohexyl methanesulfonate 
• 1544664-03-0 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid 
• 1544664-00-7 methyl 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoate 
• 1544663-98-0 6-bromo-1-(trifluoromethyl)-2-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 

Relevant articles and documents

Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization

Reported here is a straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates the preferential addition of hydrogen to the substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction. This strategy enables the diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes and saturated heterocycles, and even allows formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicate that hydrogen preferentially attacks the substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as the reactive species, followed by either reversible or irreversible hydrogen addition to the nonsubstitution sites.

Method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation

The invention discloses a method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation. The method is characterized in that trifluoromethylaromatic hydrocarbons or trifluoromethyl heterocyclic compounds ar

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.