Journal of Organic Chemistry p. 4156 - 4158 (1983)
Update date:2022-08-05
Topics:
Taylor, Stephen L.
Lee, David Y.
Martin, J. C.
Efficient synthetic routes to 2-substituted pyridines and 2,6-disubstituted pyridine 1-oxides involving direct lithiation with the sterically hindered base lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the presence of electrophiles that are compatible with the base, e.g., trimethylsilyl chloride (Me3SiCl) and hexafluoroacetone (HFA), are described.
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