Macrofusine

Base Information

• Chemical Name: Macrofusine
• CAS No.: 116355-83-0
• Molecular Formula: C₃₄H₅₉NO₁₅
• Molecular Weight: 721.84
• Hs Code.: 29221990
• European Community (EC) Number: 621-436-3,808-555-8
• NSC Number: 629151
• DSSTox Substance ID: DTXSID80861237
• Nikkaji Number: J449.142D
• Wikipedia: Fumonisin_B1
• NCI Thesaurus Code: C1107
• ChEMBL ID: CHEMBL1588379
• Mol file: 116355-83-0.mol

Synonyms:fumonisin B(1);fumonisin B1;fumonisin-B1

Chemical Property of Macrofusine

Chemical Property:

• Appearance/Colour: white to tan powder
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 924.914 °C at 760 mmHg
• PKA: 3?+-.0.23(Predicted)
• Flash Point: 513.17 °C
• PSA: 288.51000
• Density: 1.255 g/cm³
• LogP: 3.26450
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water (up to 25 mg/ml).
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 31
• Exact Mass: 721.38847018
• Heavy Atom Count: 50
• Complexity: 1070

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fumonisin B1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, T, F
• Hazard Codes: Xn,T,F
• Statements: 40-36-20/21/22-11
• Safety Statements: 36/37-16-26-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Mycotoxins
• Canonical SMILES: CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
• Description: Fumonisin B1 (116355-83-0) inhibits ceramide synthesis (sphinganine N-acyltransferase), IC50 = 100 nM. Inhibits de novo sphingolipid biosynthesis (IC50 = 0.7 μM) thereby blocking glycosphingolipid production.
• Uses: A mycotoxin produced by mold associated with corn. Fungal metabolite believed to cause leukoencephalomalacia in horses. Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons. A serine/threonine phosphatase inhibitor.