CO-1686

Base Information Edit

Chemical Name:CO-1686
CAS No.:1374640-70-6
Molecular Formula:C27H28F3N7O3
Molecular Weight:555.56
Hs Code.:29335990
Mol file:1374640-70-6.mol

Synonyms:CO-1686;AVL-301;CNX-419;CO-1686 (AVL-301);CO-1686/CO1686;N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;Clovis CO-1686;CO-1686(free base)

Suppliers and Price of CO-1686

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CO1686
100mg
$ 275.00

Matrix Scientific
N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%
1g
$ 1170.00

Matrix Scientific
N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 97%
5g
$ 3510.00

DC Chemicals
Rociletinib(CO-1686) >99%
100 mg
$ 200.00

Crysdot
CO-1686 98+%
100mg
$ 271.00

ChemScene
Rociletinib 99.59%
5mg
$ 50.00

ChemScene
Rociletinib 99.59%
50mg
$ 150.00

ChemScene
Rociletinib 99.59%
10mg
$ 80.00

ChemScene
Rociletinib 99.59%
100mg
$ 250.00

Chemenu
N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 98%
100mg
$ 230.00

Total 107 raw suppliers

Chemical Property of CO-1686 Edit

Chemical Property:

PKA:13.23±0.70(Predicted)
PSA：118.44000
Density:1.372±0.06 g/cm3(Predicted)
LogP:4.93150
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

CO1686 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 23-25-36
Safety Statements: 24

MSDS Files:: SDS file from LookChem

Useful:

Description CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (Ki = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI50 values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.
Uses CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.

Technology Process of CO-1686

There total 19 articles about CO-1686 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%