Dimethyl 3-bromopyridine-2,6-dicarboxylate

Base Information

• Chemical Name: Dimethyl 3-bromopyridine-2,6-dicarboxylate
• CAS No.: 316808-11-4
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Hs Code.: 2933399090
• Mol file: 316808-11-4.mol

Synonyms:Dimethyl 3-bromopyridine-2,6-dicarboxylate

Chemical Property of Dimethyl 3-bromopyridine-2,6-dicarboxylate

Chemical Property:

• Boiling Point: 370.4±37.0 °C(Predicted)
• PKA: -3.06±0.10(Predicted)
• PSA: 65.49000
• Density: 1.569±0.06 g/cm3(Predicted)
• LogP: 1.41730
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

Dimethyl3-bromopyridine-2,6-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl 3-bromopyridine-2,6-dicarboxylate

There total 5 articles about Dimethyl 3-bromopyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

methanol (67-56-1) + 3-bromo-pyridine-2,6-dicarboxylic acid (316808-10-3) → 3-bromo-pyridine-2,6-dicarboxylic acid dimethyl ester (316808-11-4)

Guidance literature:

With sulfuric acid; at 65 ℃; for 5.3h; Heating; Large scale;

Reference yield:

3-bromo-2,6-dimethylpyridine (3430-31-7) → 3-bromo-pyridine-2,6-dicarboxylic acid dimethyl ester (316808-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 29.8 g / KMnO₄ / H₂O / 12 h / 90 °C

2: thionyl chloride / 4 h / Heating

3: 25.0 g / 1 h / Heating

With potassium permanganate; thionyl chloride; In water;

DOI:10.1016/j.bioorg.2003.09.001

Reference yield:

2,6-dimethylpyridine (108-48-5) → 3-bromo-pyridine-2,6-dicarboxylic acid dimethyl ester (316808-11-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / oleum; bromine / 18 h / 150 °C

2: 29.8 g / KMnO₄ / H₂O / 12 h / 90 °C

3: thionyl chloride / 4 h / Heating

4: 25.0 g / 1 h / Heating

With potassium permanganate; thionyl chloride; sulfuric acid; bromine; In water;

DOI:10.1016/j.bioorg.2003.09.001

upstream raw materials:

methanol

2,6-dimethylpyridine

3-bromo-2,6-dimethylpyridine

3-bromo-pyridine-2,6-dicarboxylic acid

Downstream raw materials:

{6-hydroxymethyl-3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxy-methyl)-tetrahydro-furan-2R-yl]-pyridin-2-yl}-methanol

3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2R-yl]-pyridine-2,6-dicarboxylic acid dimethyl ester

3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2R-yl]-pyridine-2,6-dicarboxylic acid

3-{5R-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4S-hydroxy-tetrahydro-furan-2R-yl}-pyridine-2,6-dicarboxylic acid dimethyl ester

Refernces

• 1、 -. "METHOD FOR PRODUCING AMIDINE DERIVATIVES". . . Retrieved 2016/03/18.