(E)-3-(4-methoxyphenyl)-N-phenylacrylamide

Base Information

• Chemical Name: (E)-3-(4-methoxyphenyl)-N-phenylacrylamide
• CAS No.: 340258-57-3
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 340258-57-3.mol

Synonyms:(E)-3-(4-methoxyphenyl)-N-phenylacrylamide

Chemical Property of (E)-3-(4-methoxyphenyl)-N-phenylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-methoxyphenyl)-N-phenylacrylamide

There total 5 articles about (E)-3-(4-methoxyphenyl)-N-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-benzenesulfonyl-3-(4-methoxy-phenyl)-N-phenyl-acrylamide → (E)-3-(4-methoxyphenyl)-N-phenylacrylamide (340258-57-3)

Guidance literature:

With samarium; In ethanol; acetic acid; at 20 ℃; for 3h;

Reference yield: 16.0%

1-methoxy-4-(3-phenylprop-2-yn-1-yl)benzene (167688-16-6) → (E)-3-(4-methoxyphenyl)-N-phenylacrylamide (340258-57-3)

Guidance literature:

With formic acid; hydroxylamine hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; at 80 ℃; for 12h; Schlenk technique;

DOI:10.1039/c3ob42444h

Reference yield:

(1E)-3-(4-methoxyphenyl)-1-phenylpropene (20442-73-3,35856-80-5) → (E)-3-(4-methoxyphenyl)-N-phenylacrylamide (340258-57-3) + (2E)-N-(4-methoxyphenyl)cinnamamide (76228-15-4)

Guidance literature:

With trimethylsilylazide; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; iron(II) chloride; In acetic acid; at 60 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201106112

upstream raw materials:

piperidine

pyridine

malonanilic acid

4-methoxy-benzaldehyde

Refernces

• 1、 Qin, Chong,Zhou, Wang,Chen, Feng,Ou, Yang,Jiao, Ning. "Iron-catalyzed C-H and C-C bond cleavage: A direct approach to amides from simple hydrocarbons". supporting information; experimental part. p. 12595 - 12599. Retrieved 2012/01/15.