LAVENDUSTIN A

Base Information

• Chemical Name: LAVENDUSTIN A
• CAS No.: 125697-92-9
• Molecular Formula: C21H19 N O6
• Molecular Weight: 381.38
• Hs Code.: 29225000
• NSC Number: 678027
• UNII: 3Y0G32G2RV
• DSSTox Substance ID: DTXSID00154855
• Nikkaji Number: J366.434A
• Wikidata: Q27164152
• NCI Thesaurus Code: C1142
• Metabolomics Workbench ID: 106021
• ChEMBL ID: CHEMBL103552
• Mol file: 125697-92-9.mol

Synonyms:LavendustinA; NSC 678027

Chemical Property of LAVENDUSTIN A

Chemical Property:

• Appearance/Colour: Off-White Solid
• Vapor Pressure: 4.23E-23mmHg at 25°C
• Melting Point: 205-215℃
• Boiling Point: 741.7°C at 760 mmHg
• PKA: 2.31±0.10(Predicted)
• Flash Point: 402.4°C
• PSA: 121.46000
• Density: 1.495±0.06 g/cm3(Predicted)
• LogP: 3.41400
• Storage Temp.: −20°C
• Sensitive.: Air Sensitive
• Solubility.: DMSO: soluble
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 381.12123733
• Heavy Atom Count: 28
• Complexity: 517

Purity/Quality:

99.3% ^*data from raw suppliers

Lavendustin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CN(CC2=C(C=CC(=C2)O)O)C3=CC(=C(C=C3)O)C(=O)O)O
• Description: Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
• Uses: A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.