Technology Process of N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide
There total 10 articles about N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
1,2-dimethoxyethane;
at 95 ℃;
for 24h;
DOI:10.1021/jm3009103
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
1.2: 0.33 h / Cooling with ice
2.1: dimethyl sulfoxide / 24 h / 20 °C
3.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C
With
potassium tert-butylate; N,N-dimethyl-aniline; trichlorophosphate;
In
1,2-dimethoxyethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C
2.2: 22 h / 20 - 31 °C
2.3: -10 °C / pH 6 - 7
3.1: sodium / methanol / 18 h / 0 - 20 °C
3.2: 4 h / 20 °C
3.3: 0.17 h
4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
4.2: 0.33 h / Cooling with ice
5.1: dimethyl sulfoxide / 24 h / 20 °C
6.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C
With
thionyl chloride; potassium tert-butylate; sodium; sodium hydride; N,N-dimethyl-aniline; trichlorophosphate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dimethyl sulfoxide;