2-Methyl-6-phenylpyridine

Base Information

• Chemical Name: 2-Methyl-6-phenylpyridine
• CAS No.: 46181-30-0
• Molecular Formula: C12H11 N
• Molecular Weight: 169.226
• Hs Code.: 2933399090
• European Community (EC) Number: 256-258-1
• DSSTox Substance ID: DTXSID30963518
• Nikkaji Number: J371.427F
• Wikidata: Q72495218
• Mol file: 46181-30-0.mol

Synonyms:2-Methyl-6-phenylpyridine;46181-30-0;EINECS 256-258-1;MFCD00796537;6-Phenyl-2-picoline;2-phenyl-6-methyl-pyridine;SCHEMBL647992;DTXSID30963518;GREMYQDDZRJQEG-UHFFFAOYSA-N;AKOS006345461;SB67028;AS-58500;SY017680;FT-0646241;M2001;T72489;EN300-6731951;A826997;W-106100

Chemical Property of 2-Methyl-6-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.6080 to 1.6120
• Boiling Point: 268.5 °C at 760 mmHg
• PKA: 5.16±0.10(Predicted)
• Flash Point: 109.6 °C
• PSA: 12.89000
• Density: 1.03 g/cm³
• LogP: 3.05700
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 169.089149355
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-6-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)C2=CC=CC=C2

Technology Process of 2-Methyl-6-phenylpyridine

There total 63 articles about 2-Methyl-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenylhex-5-yn-1-one oxime (1201003-23-7) → 6-methyl-2-phenylpyridine (46181-30-0)

Guidance literature:

1-phenylhex-5-yn-1-one oxime; With toluene-4-sulfonic acid; In chlorobenzene; at 180 ℃; for 8h; Microwave irradiation; Inert atmosphere;

With triethylamine; In chlorobenzene;

DOI:10.1002/anie.200903922

Reference yield: 99.0%

6-chloro-2-picoline (18368-63-3) + phenylboronic acid (98-80-6) → 6-methyl-2-phenylpyridine (46181-30-0)

Guidance literature:

With potassium phosphate monohydrate; 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; palladium diacetate; In 1,4-dioxane; at 135 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201200355

Reference yield: 99.0%

6-methylpyridin-2-yl fluorosulfate + phenylboronic acid (98-80-6) → 6-methyl-2-phenylpyridine (46181-30-0)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In ethanol; water; at 35 ℃; for 3h; chemoselective reaction;

DOI:10.1002/chem.201600167

upstream raw materials:

6-phenyl-hexa-3,5-dien-2-one oxime

α-picoline

phenylmagnesium chloride

4-methyl-2-phenyl-6H-1,3-oxazin-6-one

Downstream raw materials:

2-methyl-6-phenylpyridin-1-ium iodide

2-methyl-6-phenylpyridin-1-ium bromide

(2R,6R)-(+)-2-methyl-6-phenylpiperidine

C₂₆H₂₄N₂O₂S

Refernces

• 1、 Li, Yuqiang,Yin, Guoyin. "Bathocuproine-Enabled Nickel-Catalyzed Selective Ullmann Cross-Coupling of Two sp 2-Hybridized Organohalides". supporting information. p. 1657 - 1661. Retrieved 2021/09/13.
• 2、 Wu, Ke,Ling, Yichen,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu,Jin, Liqun,Hu, Xinquan. "Ni-catalyzed reductive decyanation of nitriles with ethanol as the reductant". supporting information. p. 2273 - 2276. Retrieved 2021/03/09.