1000669-72-6

Basic information

• Product Name: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
• Synonyms: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;KW 2449;(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone;KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride;[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone
• CAS NO: 1000669-72-6
• Molecular Formula: C20H20N4O
• Molecular Weight: 332.41
• Product Categories: Inhibitor;Inhibitors
• Mol File: 1000669-72-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 604.093 °C at 760 mmHg
• Flash Point: 319.144 °C
• Appearance: /
• Density: 1.28
• Storage Temp.: -20°C
• Solubility: Soluble in DMSO (>25 mg/ml)
• PKA: 13.76±0.40(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• CAS DataBase Reference: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone(1000669-72-6)
• EPA Substance Registry System: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone(1000669-72-6)

Safety Data

• Hazardous Substances Data: 1000669-72-6(Hazardous Substances Data)

Usage

Description

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone, also known as KW-2449, is a potent multikinase inhibitor with IC50 values of 7 nM for FLT3, 36 nM for FGFR1, 14 nM for Abl, and 4 nM for Abl-T315. It exhibits anti-leukemic effects and has potential applications in various industries.
Used in Pharmaceutical Industry:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone is used as a multikinase inhibitor for its anti-leukemic effects. It targets multiple kinases, including FLT3, FGFR1, and Abl, making it a promising candidate for the treatment of leukemia and other related cancers.
Used in Cancer Research:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone is used as a research tool for studying the role of multikinase inhibition in cancer development and progression. Its ability to target multiple kinases allows researchers to investigate the underlying mechanisms of cancer growth and identify potential therapeutic targets.
Used in Drug Development:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone is used as a lead compound in the development of new drugs targeting multikinase pathways. Its potent inhibitory activity against various kinases makes it a valuable starting point for designing and optimizing novel therapeutic agents for cancer treatment.

References

Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938