100938-11-2

Basic information

• Product Name: ATRACTYLOSIDE SODIUM SALT
• Synonyms: GLYCOSIDE;ATRACTYLOSIDE SODIUM;ATRACTYLOSIDE SODIUM SALT;ATRACTYLOSIDE;Atraotydin;ATRACTYLOSIDE SODIUM SALT FROM ATRACTYLIS GUMMIFERA;(2β,4α,15α)-15-Hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic Acid DisodiuM Salt;Atractylic Acid DisodiuM Salt
• CAS NO: 100938-11-2
• Molecular Formula: C30H44Na2O16S2
• Molecular Weight: 770.77
• Product Categories: Miscellaneous Natural Products
• Mol File: 100938-11-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ATRACTYLOSIDE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: ATRACTYLOSIDE SODIUM SALT(100938-11-2)
• EPA Substance Registry System: ATRACTYLOSIDE SODIUM SALT(100938-11-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45
• RIDADR: 3172
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 100938-11-2(Hazardous Substances Data)

Usage

Description

ATRACTYLOSIDE SODIUM SALT is a white solid that acts as a specific inhibitor of the adenine nucleotide translocase (ANT), a mitochondrial ADP/ATP carrier. It is also recognized as a proapoptotic ligand of ANT, which induces pore formation by ANT and leads to the permeabilization of the mitochondrial membrane. Studies have shown that Atractyloside inhibits chloride channels from the mitochondrial membrane and is used to investigate the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, particularly in relation to death receptor-mediated apoptosis.

Uses

Used in Pharmaceutical Applications:
ATRACTYLOSIDE SODIUM SALT is used as a research compound for studying the mechanisms of apoptosis and mitochondrial function. Its ability to induce pore formation by ANT and permeabilize the mitochondrial membrane makes it a valuable tool in understanding the processes involved in cell death and potential therapeutic targets for various diseases.
Used in Tumor Necrosis Factor Cytotoxicity Studies:
ATRACTYLOSIDE SODIUM SALT is used as an inducer of the release of hyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells. This application is crucial for studying the cytotoxic effects of tumor necrosis factor and its role in various pathological conditions.
Used in Apoptosis Research:
ATRACTYLOSIDE SODIUM SALT is used as a probe to investigate the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells. This helps researchers understand the molecular mechanisms underlying death receptor-mediated apoptosis, which is essential for developing targeted therapies for various diseases.
Used in Mitochondrial Function Studies:
ATRACTYLOSIDE SODIUM SALT is used as an inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. This application is vital for studying the role of ANT in mitochondrial function and its potential as a therapeutic target for conditions related to mitochondrial dysfunction.
Used in Chloride Channel Inhibition Studies:
ATRACTYLOSIDE SODIUM SALT is used to inhibit chloride channels from the mitochondrial membrane. This application is important for understanding the role of these channels in cellular processes and their potential as targets for therapeutic intervention in various diseases.