10111-08-7 Usage
Chemical Properties
White to light brown solid
Uses
Different sources of media describe the Uses of 10111-08-7 differently. You can refer to the following data:
1. 1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
2. Used in a study of the imidazole-directed allylation of aldimines.1
3. Imidazole-2-carboxaldehyde is a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with an important application to treat type-2 diabetes. It is used in the preparation of tridentate Schiff-base carboxylate-containing ligands by undergoing condensation reaction with amino acids beta-alanine and 2-aminobenzoic acid. It is also involved in the study of the imidazole-directed allylation of aldimines.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 7, p. 287, 1990The Journal of Organic Chemistry, 60, p. 1090, 1995 DOI: 10.1021/jo00109a052
Check Digit Verification of cas no
The CAS Registry Mumber 10111-08-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,1 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10111-08:
(7*1)+(6*0)+(5*1)+(4*1)+(3*1)+(2*0)+(1*8)=27
27 % 10 = 7
So 10111-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H4N2O/c7-3-4-5-1-2-6-4/h1-3H,(H,5,6)
10111-08-7Relevant articles and documents
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Bastiaansen,Godefroi
, p. 1603 (1978)
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Bu3SnH mediated oxidative radical cyclisation onto imidazoles and pyrroles
Aldabbagh, Fawaz,Russell Bowman,Mann, Emma,Slawin, Alexandra M.Z.
, p. 8111 - 8128 (1999)
A new protocol using radical cyclisation has been developed for the synthesis of [1,2-c]-fused imidazoles and [1,2-a]-fused pyrroles. The intermediate nucleophilic N-alkyl radicals, generated using Bu3SnH from N- (ω-bromoalkyl) or N-[ω-(phenylselanyl)alkyl] imidazoles and pyrroles, undergo regio-selective radical cyclisalion onto the azole rings followed by oxidative re-aromatisation.
Improved synthesis of imidazole-2-carboxaldehyde, imidazole-2-carboxylic acid, and ethyl imidazole-2-carboxylate
Galeazzi,Guzman,Nava,Liu,Maddox,Muchowski
, p. 1090 - 1092 (1995)
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Photoinduced electron-transfer-promoted redox fragmentation of N-alkoxyphthalimides
Zlotorzynska, Maria,Sammis, Glenn M.
supporting information; experimental part, p. 6264 - 6267 (2012/01/15)
A new photoinduced electron-transfer-promoted redox fragmentation of N-alkoxyphthalimides has been developed. Mechanistic experiments have established that this reaction proceeds through a unique concerted intramolecular fragmentation process. This distinctive mechanism imparts many synthetic advantages, which are highlighted in the redox fragmentation of various heterocyclic substrates.
