104-78-9 Usage
Description
3-Diethylaminopropylamine is a water-white liquid with a fish-like odor, characterized by its clear colorless to slightly yellowish appearance. It has a flash point of 138°F and may be very irritating to skin and eyes. 3-Diethylaminopropylamine is primarily used to make other chemicals and serves as a component of adhesives.
Uses
Used in Chemical Synthesis:
3-Diethylaminopropylamine is used as an intermediate in the synthesis of various chemicals, playing a crucial role in the production of different compounds.
Used in Adhesives:
As a component of adhesives, 3-Diethylaminopropylamine contributes to the formulation and performance of these bonding agents.
Used in Solvent Applications:
3-Diethylaminopropylamine is used as a solvent, which helps dissolve other substances in various industrial processes.
Used in Extraction Agents:
3-Diethylaminopropylamine serves as an extraction agent, facilitating the separation and purification of different materials.
Used in Organic Synthesis Intermediates:
3-Diethylaminopropylamine is utilized as an intermediate in organic synthesis, enabling the creation of a wide range of organic compounds.
Used in Dyes and Pigments:
It is employed in the production of dyes and pigments, contributing to their color and properties.
Used in Surface Active Agents:
3-Diethylaminopropylamine is used in the formulation of surface active agents, which are essential in various industries for their ability to lower surface tension and improve the performance of products.
Used in Biocompatible Polyampholyte-coated Magnetite Nanoparticles:
3-(Diethylamino)propylamine is used in the preparation of biocompatible polyampholyte-coated (poly(acrylic acid)-co-3-(diethylamino)-propylamine magnetite nanoparticles (PAMNPs), which have potential applications in the biomedical field.
Used in Hyaluronic Acid-grafted Nanoparticles:
It is also used in the synthesis of hyaluronic acid grafted with 3-diethylaminopropyl (DEAP) group (HA-g-DEAP) nanoparticles, which can be employed as a drug delivery vehicle.
Used in DEAPA-modified Polymers for Gene Silencing:
3-Diethylaminopropylamine is utilized in the modification of poly(vinyl alcohol) (PVA) polymers to create DEAPA-modified PVA polymers, which can be employed in gene silencing applications.
Used in Surface Modification of Microfibrillated Cellulose:
3-Diethylaminopropylamine may also be used to introduce cationic groups during the surface modification of microfibrillated cellulose (MFC), enhancing its properties and applications in various industries.
Air & Water Reactions
Flammable.
Reactivity Profile
3-Diethylaminopropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Hazard
Moderate fire risk. Irritant to skin.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Moderately toxic by
ingestion and skin contact. Corrosive to the
eyes, skin, and mucous membranes. A
sensitizer. See also AMINES. Flammable
liquid when exposed to heat or flame; can
react with oxidzing materials. To fight fire,
use foam, CO2, dry chemical. When heated
to decomposition it emits toxic fumes of
NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 104-78-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104-78:
(5*1)+(4*0)+(3*4)+(2*7)+(1*8)=39
39 % 10 = 9
So 104-78-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H18N2/c1-3-9(4-2)7-5-6-8/h3-8H2,1-2H3/p+2
104-78-9Relevant articles and documents
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Utermohlen,Hamilton
, p. 156,158 (1941)
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New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis
Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale
, p. 304 - 317 (2019/02/07)
Cdc2-like kinase 1 (CLK1) and dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) are involved in the regulation of alternative pre-mRNA splicing. Dysregulation of this process has been linked to cancer progression and neurodegenerative diseases, making CLK1 and DYRK1A important therapeutic targets. Here we describe the synthesis of new pyrido[3,4-g]quinazoline derivatives and the evaluation of the inhibitory potencies of these compounds toward CDK5, CK1, GSK3, CLK1 and DYRK1A. Introduction of aminoalkylamino groups at the 2-position resulted in several compounds with low nanomolar affinity and selective inhibition of CLK1 and/or DYRK1A. Their evaluation on several immortalized or cancerous cell lines showed varying degree of cell viability reduction. Co-crystal structures of CLK1 with two of the most potent compounds revealed two alternative binding modes of the pyrido[3,4-g]quinazoline scaffold that can be exploited for future inhibitor design.
Highly efficient reduction of carbonyls, azides, and benzyl halides by NaBH4 in water catalyzed by PANF-immobilized quaternary ammonium salts
Du, Jianguo,Xu, Gang,Lin, Huikun,Wang, Guangwei,Tao, Minli,Zhang, Wenqin
supporting information, p. 2726 - 2735 (2016/05/24)
A series of polyacrylonitrile fiber-supported quaternary ammonium salts (PANF-QAS) were prepared and applied to the catalytic reduction of aldehydes, ketones, azides, and benzyl halides in water using NaBH4 as the reducing reagent in a highly efficient, economic, and environmentally benign way. The structure-activity relationships were investigated, which showed that the catalysts made up of quaternary ammonium salts with longer alkyl chains, larger cationic radii and better lipophilicity speed up the reduction reaction to afford the products in excellent yield. Moreover, the optimized catalyst can be applied to the reduction of 1-naphthaldehyde in a continuous flow process with outstanding reactivity and recyclability.