108321-05-7 Usage
Description
5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT, also known as 5-Phospho-D-ribose 1-Diphosphate, is a natural intermediate that plays a crucial role in the pentose phosphate pathway. This pathway is involved in the metabolism of purine, pyrimidine, and histidine. It is characterized by its white powder form.
Uses
Used in Biochemical Research:
5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT is used as a biochemical research tool for studying the pentose phosphate pathway and its role in the metabolism of various biomolecules, including purine, pyrimidine, and histidine.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT is used as a key intermediate in the synthesis of various drugs targeting the pentose phosphate pathway. This can lead to the development of new therapeutic agents for treating diseases associated with disruptions in purine, pyrimidine, and histidine metabolism.
Used in Diagnostic Applications:
5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT can be employed as a diagnostic marker in clinical settings to assess the activity of the pentose phosphate pathway and monitor the metabolic status of patients with related disorders.
Used in Nutritional Supplements:
As a component of the pentose phosphate pathway, 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT may be used in nutritional supplements to support the body's metabolic processes and maintain overall health.
Used in Agricultural Applications:
In agriculture, 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT can be utilized to enhance the growth and development of crops by promoting the metabolic processes involved in purine, pyrimidine, and histidine synthesis. This can lead to improved crop yields and quality.
Check Digit Verification of cas no
The CAS Registry Mumber 108321-05-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,2 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 108321-05:
(8*1)+(7*0)+(6*8)+(5*3)+(4*2)+(3*1)+(2*0)+(1*5)=87
87 % 10 = 7
So 108321-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5-;;;;/m1..../s1
108321-05-7Relevant articles and documents
Practical Synthesis of 5-Phospho-D-ribosyl α-1-pyrophosphate (PRPP): Enzymatic Routes from Ribose 5-Phosphate or Ribose
Gross, Akiva,Abril, Obsidiana,Lewis Jerome M.,Geresh, Shimona,Whitesides, George M.
, p. 7428 - 7435 (2007/10/02)
This paper describes enzymatic syntheses of 5-phospho-D-ribosyl α-1-pyrophosphate (PRPP) on a 75-mmol scale.The reactions used PAN-immobilized PRPP synthetase as catalyst with in situ ATP-cofactor regeneration.In one procedure pure r-5-P was used as a starting material; in a second, r-5-P was synthesized by ribokinase-catalyzed phosphorilation of D-ribose and used in situ.The potential for use of PRPP as a starting material for the preparation of nucleotides was demonstrated by an enzymatic synthesis of UMP.This paper also describes several methods for the preparation of r-5-P: acid-catalyzed hydrolysis of AMP, acid-catalyzed hydrolysis of crude mononucleotide mixture obtained by digestion of RNA, chemical synthesis from D-ribose, and ribokinase-catalyzed synthesis from D-ribose.Procedures are described for the isolation of PRPP synthetase (from Salmonella typhimurium) and ribokinase (from Lactobacillus plantarum) and for immobilization of these enzymes in PAN.
