108341-18-0

Basic information

• Product Name: L-NORADRENALINE BITARTRATE
• Synonyms: L-Arterenol hydrogen L-tartrate;L-Norepinephrine bitartrate salt;L-(-)-Norepinephrine (bitartrate hydrate);Levarterenol bitartrate monohydrate;4-[(1R)-2-amino-1-hydroxyethyl]-1,2-Benzenediol (2R,3R)-2,3-dihydroxybutanedioate hydrate (1:1:1);L-NORADRENALINE BITARTRATE;L-(-)-NOREPINEPHRINE-(+)-BITARTRATE;L-NOREPINEPHRINE BITARTRATE
• CAS NO: 108341-18-0
• Molecular Formula: C12H17NO9
• Molecular Weight: 319.26
• EINECS: 1806241-263-5
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Steroids;Levophed
• Mol File: 108341-18-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 100-104 °C(lit.)
• Boiling Point: 442.6 °C at 760 mmHg
• Flash Point: 221.5 °C
• Appearance: white/
• Vapor Pressure: 1.3E-08mmHg at 25°C
• Refractive Index: -11 ° (C=5, H2O)
• Storage Temp.: Refrigerator
• Solubility: H2O: soluble50mg/mL, clear
• PKA: 8.64(at 25℃)
• BRN: 4078502
• CAS DataBase Reference: L-NORADRENALINE BITARTRATE(CAS DataBase Reference)
• NIST Chemistry Reference: L-NORADRENALINE BITARTRATE(108341-18-0)
• EPA Substance Registry System: L-NORADRENALINE BITARTRATE(108341-18-0)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28-28
• Safety Statements: 22-26-36/37/39-45-36/37-28
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: DN6750000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 108341-18-0(Hazardous Substances Data)

Usage

Description

L-NORADRENALINE BITARTRATE, also known as Levophed, is a sympathomimetic hormone that acts as a direct alpha-adrenergic receptor stimulator. It is a demethylated precursor of epinephrine (adrenaline), which is produced by the adrenal gland. L-NORADRENALINE BITARTRATE is a white solid with chemical properties that make it suitable for various applications.

Uses

Used in Pharmaceutical Industry:
L-NORADRENALINE BITARTRATE is used as a direct alpha-adrenergic receptor stimulator for treating conditions that require vasoconstriction, such as hypotension and shock.
L-NORADRENALINE BITARTRATE is also used as a direct beta-adrenergic receptor stimulator (specifically beta1-adrenergic receptors) for the heart, which can help increase heart rate and contractility in certain cardiovascular conditions.
Used in Chemical Synthesis:
L-NORADRENALINE BITARTRATE serves as a demethylated precursor of epinephrine (adrenaline), making it a valuable intermediate in the synthesis of various pharmaceutical compounds and medications.
Used in Research and Development:
As a sympathomimetic hormone, L-NORADRENALINE BITARTRATE is utilized in research and development for studying the effects of adrenergic stimulation on various physiological processes and the development of new drugs targeting adrenergic receptors.

Biochem/physiol Actions

Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter.

InChI:InChI=1/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1