111011-76-8

Basic information

• Product Name: EFONIDIPINE
• Synonyms: Efonidipine hydrochloride monoethanolate;Efonidipine Hydrochloride ethanol (1:1:1);2-(phenyl(phenylmethyl)amino)ethyleste;3-pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxa;efonidipinehydrochlorideethanolate;nz-105;nz105ethanolate;r,p-oxide,monohydrochloride
• CAS NO: 111011-76-8
• Molecular Formula: C34H38N3O7P
• Molecular Weight: 631.66
• Mol File: 111011-76-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 151° (dec)
• Boiling Point: 746.9 °C at 760 mmHg
• Flash Point: 405.5 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 3.5E-22mmHg at 25°C
• Storage Temp.: Desiccate at +4°C
• CAS DataBase Reference: EFONIDIPINE(CAS DataBase Reference)
• NIST Chemistry Reference: EFONIDIPINE(111011-76-8)
• EPA Substance Registry System: EFONIDIPINE(111011-76-8)

Safety Data

• Hazardous Substances Data: 111011-76-8(Hazardous Substances Data)

Usage

Description

Efonidipine, also known as Efonidipine Hydrochloride Monoethanolate, is a dihydropyridine (DHP) calcium channel blocker used for the treatment of essential hypertension and renal hypertension. It functions by binding to the DHP receptors on voltage-dependent calcium channels, causing diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are slow in onset and long-lasting, and it exhibits an improved side effect profile compared to other drugs in the same class. Additionally, it may suppress the development of atherosclerosis without affecting plasma lipids.

Uses

Used in Pharmaceutical Industry:
Efonidipine is used as an antihypertensive agent for the treatment of essential and renal hypertension. It is effective in reducing blood pressure and improving cardiovascular health in patients with hypertension.
Used in Cardiovascular Applications:
Efonidipine is used as a vasodilator and calcium antagonist to improve blood flow and reduce the workload on the heart. Its slow and long-lasting effects make it a suitable option for managing cardiovascular conditions.
Used in Angina Treatment:
Efonidipine is used as a treatment for angina, a condition characterized by chest pain due to insufficient blood flow to the heart. Its vasodilating properties help to alleviate chest pain and improve blood flow to the heart.
Used in Cerebrovascular Disorders:
Efonidipine is used for the treatment of cerebrovascular disorders, such as stroke and transient ischemic attacks. Its cerebrovasodilatory effects help to improve blood flow to the brain and reduce the risk of further complications.
Used in Atherosclerosis Prevention:
Efonidipine is used as a preventive measure against the development of atherosclerosis, a condition where plaque builds up inside the arteries. Its ability to suppress atherosclerosis without affecting plasma lipids makes it a valuable option for maintaining cardiovascular health.
Brand Name: Landel

Originator

Nissan Chemical (Japan)

Biological Activity

Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

InChI:InChI=1/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H