111917-59-0

Basic information

• Product Name: Adenanthin
• Synonyms: Adenanthin;Actinodephnine Acuminatin Acuminatoside Adenanthin
• CAS NO: 111917-59-0
• Molecular Formula: C₂₆H₃₄O₉
• Molecular Weight: 490.54
• Mol File: 111917-59-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Adenanthin(CAS DataBase Reference)
• NIST Chemistry Reference: Adenanthin(111917-59-0)
• EPA Substance Registry System: Adenanthin(111917-59-0)

Safety Data

• Hazardous Substances Data: 111917-59-0(Hazardous Substances Data)

Usage

Enzyme inhibitor

This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid.

Downstream Products

• 111943-09-0 16,17-dihydro-3,7-di-p-bromobenzoate derivative of adenanthin