114570-69-3Relevant articles and documents
Regiospecific Aza-Michael Addition of 4-Aryl-1 H -1,2,3-triazoles to Chalcones: Synthesis of 2,4-Disubstituted 1,2,3-Triazoles in Basic Medium
Bhagat, Ujjawal Kumar,Peddinti, Rama Krishna
, p. 99 - 105 (2018)
A novel metal-free and base-mediated method to display the donor ability of 1,2,3-triazoles for the synthesis of 2,4-disubstituted 1,2,3-triazoles has been developed. A DABCO-promoted aza-Michael addition of 4-aryl NH-1,2,3-triazoles to α,β-unsaturated ketones (chalcones) is presented. The reactions proceeded with complete regiospecificity in a 3:1 mixture of acetonitrile and methanol at 85 °C to provide 2,4-disubstituted 1,2,3-triazoles as Michael adducts, and the addition products 1,3-diaryl-(4-aryl-2 H -1,2,3-triazol-2-yl)propan-1-ones were isolated in high yields.
Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor
Ahmad, Pervez,Woo, Hyunjung,Jun, Kyu-Yeon,Kadi, Adnan A.,Abdel-Aziz, Hatem A.,Kwon, Youngjoo,Rahman, A.F.M. Motiur
, p. 1898 - 1908 (2016)
A series of pyrazoline derivatives (5) were synthesized in 92-96% yields from chalcones (3) and hydrazides (4). Subsequently, topo-I and IIα-mediated relaxation and antiproliferative activity assays were evaluated for 5. Among the tested compounds, 5h had
Design, synthesis, and antifungal activity evaluation of novel 2-cyano-5-oxopentanoic acid derivatives as potential succinate dehydrogenase inhibitors
Mai, Yong-zhan,Peng, Mi-jun,Tang, Xiao-rong,Wang, Xue-song
, p. 94 - 107 (2021/11/22)
Two series of novel 2-cyano-5-oxopentanoic acid derivatives (1a?l, 2a?l) were designed, synthesized, and characterized by IR, 1H NMR, 13C NMR, and HRMS. Their in vitro antifungal activity against five plant pathogenic fungi were then
N-(4-fluorophenyl)-4,5-dihydropyrazole compounds and application thereof in farm chemicals
-
Paragraph 0055-0057, (2020/05/01)
The invention relates to N-(4-fluorophenyl)-4,5-dihydropyrazole compounds and application thereof in farm chemicals, and belongs to the technical field of farm chemicals. The technical problem solvedby the present invention is to provide novel compounds t