1181230-38-5

Basic information

• Product Name: 2-(2-chlorophenyl)cyclopropanecarboxylic acid
• Synonyms: 2-(2-chlorophenyl)cyclopropanecarboxylic acid;2-(2-chlorophenyl)cyclopropane-1-carboxylic acid
• CAS NO: 1181230-38-5
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.63026
• EINECS: -0
• Mol File: 1181230-38-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-chlorophenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)cyclopropanecarboxylic acid(1181230-38-5)
• EPA Substance Registry System: 2-(2-chlorophenyl)cyclopropanecarboxylic acid(1181230-38-5)

Safety Data

• Hazardous Substances Data: 1181230-38-5(Hazardous Substances Data)

Usage

Description

2-(2-chlorophenyl)cyclopropanecarboxylic acid is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by the presence of a cyclopropane ring and a chlorophenyl group, which contribute to its unique chemical properties and potential applications in the medical field.

Uses

Used in Pharmaceutical Industry:
2-(2-chlorophenyl)cyclopropanecarboxylic acid is used as a chemical intermediate for the preparation of N-[(phenylsulfonylamino)tetrahydronaphthyl]cyclopropanecarboxamides. These compounds are potassium channel inhibitors that play a crucial role in the treatment of cardiac arrhythmias, helping to regulate the electrical activity of the heart and maintain a normal heart rhythm.

Upstream product

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Relevant articles and documents

Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound tranylcypromine: Identification of drugs with antidepressant-like action

We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a lead compound in a high-throughput screening campaign. Starting from 9, which shows modest activity as a 5-HT2C agonist, a series of 1-aminomethyl-2- phenylcyclopropanes was investigated as 5-HT2C agonists through iterative structural modifications. Key pharmacophore feature of this new class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted be zene ring. Among the tested compounds, several were potent and efficacious 5-HT2C receptor agonists with selectivity over both 5-HT2A and 5-HT2B receptors in functional assays. The most promising compound is 37, with 120- and 14-fold selectivity over 5-HT 2A and 5-HT2B, respectively (EC50) 585, 65, and 4.8 nM at the 2A, 2B, and 2C subtypes, respectively). In animal studies, compound 37 (10-60 mg/kg) decreased immobility time in the mouse forced swim test.

Arylcyclopropylcarboxylic amides as potassium channel openers

The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined

1,2,3-TRIAZOLO[4,5-D]PYRIMIDINES AS P2T RECEPTOR ANTAGONISTS

Compounds of formula having the following stereochemistrywherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists