1206524-84-6 Usage
Description
8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-, Methyl ester, (1aR,5S,8S,10R,22aR)is a complex organic compound with a unique molecular structure. It is an antiviral agent and an intermediate in the synthesis of Grazoprevir (M424985), a second-generation NS3/4A protease inhibitor. 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-, Methyl ester, (1aR,5S,8S,10R,22aR)has gained significance in COVID-19-related research.
Uses
Used in Pharmaceutical Industry:
8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-, Methyl ester, (1aR,5S,8S,10R,22aR)is used as an antiviral agent for the development of treatments against various viral infections.
Used in COVID-19 Research:
8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-, Methyl ester, (1aR,5S,8S,10R,22aR)is used as a research product in the development of potential treatments and therapies for COVID-19, the disease caused by the SARS-CoV-2 virus.
Used in Synthesis of Grazoprevir:
8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-, Methyl ester, (1aR,5S,8S,10R,22aR)serves as an intermediate in the synthesis of Grazoprevir (M424985), a second-generation NS3/4A protease inhibitor used in the treatment of hepatitis C virus (HCV) infections.
Check Digit Verification of cas no
The CAS Registry Mumber 1206524-84-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,5,2 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1206524-84:
(9*1)+(8*2)+(7*0)+(6*6)+(5*5)+(4*2)+(3*4)+(2*8)+(1*4)=126
126 % 10 = 6
So 1206524-84-6 is a valid CAS Registry Number.
1206524-84-6Relevant articles and documents
Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
Xu, Feng,Kim, Jungchul,Waldman, Jacob,Wang, Tao,Devine, Paul
, p. 7261 - 7265 (2018/11/23)
An efficient synthesis of grazoprevir is reported. Starting from four readily available building blocks, grazoprevir is prepared in 51% overall yield and >99.9% purity for pharmaceutical use.
METHODS AND INTERMEDIATES FOR THE PREPARATION OF MACROLACTAMS
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, (2015/07/07)
The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
METHODS AND INTERMEDIATES FOR THE PREPARATION OF MACROLACTAMS
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Page/Page column 41, (2015/07/07)
The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.