121521-90-2 Usage
Description
Lithospermic acid B, also known as Salvianolic acid B (Sal B), is one of the main water-soluble bioactive components derived from the medicinal plant Salvia miltiorrhiza. It is a yellow solid with potent antioxidant properties and has been traditionally used in the treatment of various ailments, including dysmenorrhea, coronary heart disease, chronic renal failure, cerebrovascular disease, hypertension, and cytotoxicity against human tumor cell lines.
Uses
Used in Pharmaceutical Applications:
Lithospermic acid B is used as a therapeutic agent for the treatment of various diseases, such as dysmenorrhea, coronary heart disease, chronic renal failure, cerebrovascular disease, and hypertension. Its application is attributed to its potent antioxidant and cytotoxic properties, which contribute to its effectiveness in managing these conditions.
Used in Antioxidant Applications:
Lithospermic acid B is used as an antioxidant due to its high total antioxidant activity, as demonstrated by the ABTS results showing EC50 values of 1.35 ± 0.00 and 1.43 ± 0.01 μg/mL for Sal A and Sal B, respectively. Its antioxidant properties make it a valuable compound for protecting cells from oxidative stress and damage.
Used in Anticancer Applications:
Lithospermic acid B is used as an anticancer agent, exhibiting cytotoxicity against human tumor cell lines. Its application in this field is due to its ability to modulate oncological signaling pathways and exert inhibitory effects on tumor growth and progression.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of lithospermic acid B, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for the delivery of lithospermic acid B, aiming to improve its therapeutic outcomes in the treatment of diseases, including cancer.
Biochem/physiol Actions
Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease. Several mechanisms of action have been proposed including EGFR, PDGF and MMP-9 inhibition and inhibition of the TGF-β1/Smads and NF-κB signaling pathways. Salvianolic acid B acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.
target
SIRT
Check Digit Verification of cas no
The CAS Registry Mumber 121521-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,5,2 and 1 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 121521-90:
(8*1)+(7*2)+(6*1)+(5*5)+(4*2)+(3*1)+(2*9)+(1*0)=82
82 % 10 = 2
So 121521-90-2 is a valid CAS Registry Number.
InChI:InChI=1/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1
