136656-07-0

Basic information

• Product Name: Timosaponin BII
• Synonyms: Timosaponin B2;Timsaponin B-Ⅱ;Timosaponin BII;(25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol;(25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol;Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge
• CAS NO: 136656-07-0
• Molecular Formula: C45H76O19
• Molecular Weight: 921.076
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products
• Mol File: 136656-07-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1033.645 °C at 760 mmHg
• Flash Point: 573℃
• Appearance: /
• Density: 1.43
• Refractive Index: 1.627
• PKA: 12.85±0.70(Predicted)
• CAS DataBase Reference: Timosaponin BII(CAS DataBase Reference)
• NIST Chemistry Reference: Timosaponin BII(136656-07-0)
• EPA Substance Registry System: Timosaponin BII(136656-07-0)

Safety Data

• Hazardous Substances Data: 136656-07-0(Hazardous Substances Data)

Usage

Description

Timosaponin BII is a bioactive compound derived from the rhizome of Anemarrhena asphodeloides, a plant that has been widely utilized in traditional Chinese medicine. It is known for its ability to modulate the processing of amyloid precursor protein, making it a promising candidate for the treatment of Alzheimer's disease.

Uses

Used in Pharmaceutical Industry:
Timosaponin BII is used as a therapeutic agent for the treatment of Alzheimer's disease. It functions as an Aβ-lowering modulator of amyloid precursor protein processing, which is a critical factor in the development of the disease. By regulating this process, Timosaponin BII has the potential to slow down or halt the progression of Alzheimer's, offering a new avenue for treatment and management of the condition.
Used in Traditional Chinese Medicine:
Timosaponin BII is also used in the context of traditional Chinese medicine, where the rhizome of Anemarrhena asphodeloides has been employed for various health-related purposes. Its incorporation into traditional remedies and formulations may provide additional benefits and applications, leveraging the plant's long history of use and the compound's specific properties.

InChI:InChI=1/C45H76O19/c1-19(18-58-40-37(55)34(52)31(49)27(15-46)60-40)7-12-45(57)20(2)30-26(64-45)14-25-23-6-5-21-13-22(8-10-43(21,3)24(23)9-11-44(25,30)4)59-42-39(36(54)33(51)29(17-48)62-42)63-41-38(56)35(53)32(50)28(16-47)61-41/h19-42,46-57H,5-18H2,1-4H3/t19-,20-,21+,22-,23+,24-,25-,26-,27+,28+,29+,30-,31+,32+,33-,34-,35-,36-,37+,38+,39+,40+,41-,42+,43-,44-,45?/m0/s1

Related news

Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of Timosaponin BII (cas 136656-07-0) in rats09/04/2019

Timosaponin BII (TBII), a major steroidal saponin isolated from Anemarrhena asphodeloides Bge., displays a variety of promising pharmacological activities, such as neuroprotection, enhancement of learning and memory, vascular protection and inhibition of platelet aggregation; therefore, it has b...detailed

Short communicationPreparation of some metabolites of Timosaponin BII (cas 136656-07-0) by biotransformation in vitro09/03/2019

Timosaponin BII (TBII) is an active constituent of some Chinese medicinal herbs, and is abundant in Anemarrhena asphodeloides Bunge. To better understand the pharmaceutical mechanisms of TBII, we prepared its deglycosylated derivatives through biotransformation with fungi Colletotrichum gloeospo...detailed