1422452-59-2

Basic information

• Product Name: (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one
• Synonyms: (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one
• CAS NO: 1422452-59-2
• Molecular Weight: 324.333
• Mol File: 1422452-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one(1422452-59-2)
• EPA Substance Registry System: (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one(1422452-59-2)

Safety Data

• Hazardous Substances Data: 1422452-59-2(Hazardous Substances Data)

Upstream product

• 699-83-2 2,6-dihydroxylacetophenone 
• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 49619-59-2 5-methoxyl-4-oxo-<1>benzopyran-3-carboxaldehyde 
• 1422452-73-0 (E)-5-methoxy-3-(3-(4-(4-methoxybenzyloxy)phenyl)-3-oxoprop-1-enyl)-4H-chromen-4-one 
• 1422452-47-8 (E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-enyl)-5-methoxy-4H-chromen-4-one 
• 165948-13-0 4'-(p-methoxybenzyl)oxy-2-bromoacetophenone 
• 1422452-71-8 1-(4-(4-methoxybenzyloxy)phenyl)-2-(triphenylphosphosphanylidene)ethanone 

Relevant articles and documents

Identification of novel chromenone derivatives as interleukin-5 inhibitors

A series of (E)-5-alkoxy-3-(3-phenyl-3-oxoprop-1-enyl)-4H-chromen-4-ones (4) and (E)-5-alkoxy-3-(3-hydroxy-3-phenylprop-1-enyl)-4H-chromen-4-ones (5) were synthesized and evaluated for their IL-5 inhibitory activity. Propenone analogs 4 possess some of the structurally important characteristics of isoflavone 2 and chalcone 3 previously known as potent IL-5 inhibitor. However, the inhibitory activity of 4 was weak and therefore this structural hybridization appears to be ineffective for the design of IL-5 inhibitor. Meanwhile the potent activity profile of compounds 5 was discovered. This enhanced activity of 5 compared to 4 could be due to the effective location of hydroxyl group of allylic alcohol moiety of 5 in the 3D structure. The electron withdrawing substituents at position 4 of phenyl ring of 5 enhances the activity possibly due to an increase in the strength of hydrogen bonding property of hydroxyl group of allylic alcohol moiety.