142763-37-9 Usage
Description
NSC 640865, with the chemical formula C17H14ClF3N2O2S, is a chemical compound also known as 3-Chloro-2-(4-(trifluoromethyl)phenyl)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid. It has been recognized for its potential as an anti-cancer agent, characterized by its ability to inhibit the growth of cancer cells through the induction of apoptosis and the suppression of tumor cell proliferation. Its mechanism of action is centered on the modulation of various cellular processes that contribute to cancer development, positioning it as a promising candidate for further research in the field of anti-cancer therapy.
Uses
Used in Pharmaceutical Industry:
NSC 640865 is used as an anti-cancer agent for its ability to induce apoptosis in cancer cells and inhibit their proliferation. It is particularly effective in targeting the cellular processes that are integral to the development and progression of cancer, making it a valuable asset in the search for novel cancer treatments.
NSC 640865 is used as a research compound for further study in understanding its mechanism of action and potential applications in cancer therapy. Its capacity to modulate cellular processes involved in cancer development offers insights into the complex interplay of biological systems in the context of oncology, potentially leading to the discovery of new therapeutic strategies and interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 142763-37-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,7,6 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 142763-37:
(8*1)+(7*4)+(6*2)+(5*7)+(4*6)+(3*3)+(2*3)+(1*7)=129
129 % 10 = 9
So 142763-37-9 is a valid CAS Registry Number.
142763-37-9Relevant articles and documents
Cyclization Reactions of the o-Naphthoquinone Diterpene Aethiopinone. A Revision of the Structure of Prionitin
Cuadrado, Maria J. Sexmero,Torre, Maria C. de la,Lin, Long-Ze,Cordell, Geoffrey A.,Rodriguez, Benjamin,Perales, Aurea
, p. 4722 - 4728 (2007/10/02)
The 4,5-seco-20(10->5)-abeo-abietane derivative aethiopinone (1), a natural o-naphthoquinone isolated from some Salvia species, was subjected to a series of acid-catalyzed reactions which yielded phenalene derivatives (2, 6, 9, and 11) and other cyclization products (3 and 10).The 11-nor derivative 3 is formed by an intramolecular cycloaddition reaction, and a mechanistic pathway for the formation of the phenalene derivatives 6 and 11 is also proposed.These transformations of aethiopinone (1) allowed the partial syntheses of the naturally occuring diterpenes salvipisone (8), salvi lenone (9), and the racemic form of prionitin (11), a rearranged abietane diterpeniod previously isolated from the root of Salvia prionitis, to which structure 12 had been attributed only on the basis of NMR spectroscopic studies.In the light of the results reported herein, including an X-ray analysis of compound 11, the structure 12 assigned to prionitin must be changed to 11.
