166180-39-8Relevant articles and documents
Hydroxymethylation of active methenyl compounds: DMSO as methylene source and H2O as oxygen source
Zhang, Liang,Liu, Shuhua,Lin, Yunliang,Wang, Yuliang
supporting information, (2022/02/25)
A mild and efficient method for hydroxymethylation of active methenyl compounds has been described. In this transformation, the widely available solvents DMSO and H2O served as methylene and oxygen sources, respectively. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds with all-carbon quaternary carbon center in good to excellent yield.
Complementing Pyridine-2,6-bis(oxazoline) with Cyclometalated N-Heterocyclic Carbene for Asymmetric Ruthenium Catalysis
Li, Long,Han, Feng,Nie, Xin,Hong, Yubiao,Ivlev, Sergei,Meggers, Eric
supporting information, p. 12392 - 12395 (2020/06/10)
A strategy for expanding the utility of chiral pyridine-2,6-bis(oxazoline) (pybox) ligands for asymmetric transition metal catalysis is introduced by adding a bidentate ligand to modulate the electronic properties and asymmetric induction. Specifically, a ruthenium(II) pybox fragment is combined with a cyclometalated N-heterocyclic carbene (NHC) ligand to generate catalysts for enantioselective transition metal nitrenoid chemistry, including ring contraction to chiral 2H-azirines (up to 97 % ee with 2000 TON) and enantioselective C(sp3)?H aminations (up to 97 % ee with 50 TON).
Preparation of β-keto esters and β-diketones by C-acylation/deacetylation of acetoacetic esters and acetonyl ketones with 1-acylbenzotriazoles
Katritzky, Alan R.,Wang, Zuoquan,Wang, Mingyi,Wilkerson, Chavon R.,Hall, C. Dennis,Akhmedov, Novruz G.
, p. 6617 - 6622 (2007/10/03)
Acyl-, aroyl-, and heteroaroyl-acetic esters 6a-f and 8a-1 are prepared by reactions of 1-acylbenzotriazoles 1a-k with acetoacetic esters 5 or 7a,b in the presence of sodium hydride followed by regioselective deacetylation. Similar C-acylation/deacetylati
