227622-98-2

Basic information

• Product Name: N-[1-(3-aminophenyl)-3-(tert-butyl)pyrazol-5-yl][(2,3-dichlorophenyl)amino]carboxamide
• Synonyms: N-[1-(3-aminophenyl)-3-(tert-butyl)pyrazol-5-yl][(2,3-dichlorophenyl)amino]carboxamide
• CAS NO: 227622-98-2
• Molecular Weight: 418.326
• Mol File: 227622-98-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[1-(3-aminophenyl)-3-(tert-butyl)pyrazol-5-yl][(2,3-dichlorophenyl)amino]carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(3-aminophenyl)-3-(tert-butyl)pyrazol-5-yl][(2,3-dichlorophenyl)amino]carboxamide(227622-98-2)
• EPA Substance Registry System: N-[1-(3-aminophenyl)-3-(tert-butyl)pyrazol-5-yl][(2,3-dichlorophenyl)amino]carboxamide(227622-98-2)

Safety Data

• Hazardous Substances Data: 227622-98-2(Hazardous Substances Data)

Upstream product

• 476637-05-5 2-(3-nitrophenyl)-5-tert-butyl-2H-pyrazol-3-yl-amine 
• 51516-96-2 3-nitrophenylhydrazine hydrochloride 
• 59997-51-2 trimethylacetylacetonitrile 
• 227622-99-3 N-(1-(3-nitrophenyl)-3-tert-butyl-5-pyrazolyl)-N'-(2,3-dichlorophenyl)urea 

Relevant articles and documents

INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,

1-Phenyl-5-pyrazolyl ureas: Potent and selective p38 kinase inhibitors

Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as small-molecule inhibitors of p38 by a combinatorial chemistry effort. Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM). (C) 2000 Elsevier Science Ltd.